{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:03:20Z","timestamp":1784351000231,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nondiagnostic cytology for thyroid nodules, consistent with The Bethesda System for Reporting Thyroid Cytopathology category I (B1) poses a management dilemma for clinicians. The objective of this study was to define the malignancy risk of nodules with B1 cytology using American College of Radiology Thyroid Imaging Reporting &amp; Data System (TI\u2010RADS) and to assess whether TI\u2010RADS can help guide the decision to perform a repeat biopsy of these nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This retrospective cohort study evaluated 139 B1 nodules that had a definitive diagnosis on repeat biopsy or surgical excision. Sonographic features were evaluated and classified according to TI\u2010RADS. TI\u2010RADS category and total points were compared to the final diagnosis to determine the malignancy risk of B1 thyroid nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 139 nodules, 11 (7.9%) were malignant. The malignancy risk of nodules assigned TI\u2010RADS category 1 and 2 were both 0%, TI\u2010RADS 3 was 2.9%, whereas TI\u2010RADS 4 and 5 were 5.9% and 46.2%, respectively. The optimal cutoff for TI\u2010RADS points predicting malignancy was 5 points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>B1 thyroid nodules in TI\u2010RADS categories 1\u20133 may not require repeat biopsy given low malignancy risk. However, B1 nodules in TI\u2010RADS categories 4 and 5 have a higher malignancy risk and thus should undergo repeat biopsy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.70093","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:04:46Z","timestamp":1775801086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Utility of ACR TI\u2010RADS to determine need for repeat FNA in thyroid nodules with nondiagnostic cytology"],"prefix":"10.1002","volume":"134","author":[{"given":"Lauren","family":"Waters","sequence":"first","affiliation":[{"name":"Division of Endocrinology NYU Langone Health  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany M.","family":"Cullen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology NYU Langone Health  Mineola New York 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