{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T10:06:40Z","timestamp":1779012400353,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The nucleus of papillary thyroid carcinoma (PTC) has had a fascinating history since its early descriptions by Lindsay in 1960 and his designation of follicular variant papillary thyroid carcinoma (FVPTC) as a subtype of follicular carcinoma (FC). Later, Chen and Rosai revived the awareness of FVPTC and aligned this neoplasm with PTC. From this era, PTC became a \u201cnuclear\u201d diagnosis and was expanded to include FVPTC, even when noninvasive and encapsulated. However, this practice was prone to interobserver variability. The main issue centered on the interpretation of two types of nuclei \u2013 the widely accepted \u201cclassical papillary nucleus\u201d with well\u2010developed features such as nuclear pseudoinclusions and grooves and the other \u201cpapillary\u2010like nucleus\u201d with subtle and delicate nuclear features. Subsequently, some individuals recognized \u201cpapillary\u2010like nucleus\u201d in most follicular\u2010patterned neoplasms and diagnosed them as FVPTC, while others diagnosed them as follicular adenoma or FC. In the 2000s, noninvasive, encapsulated FVPTC was recognized as an indolent entity, and later relabeled as noninvasive follicular thyroid neoplasm with papillary\u2010like nuclear features (NIFTP). Molecular analyses revealed two main families of drivers for PTC \u2010 BRAF V600E or BRAF V600E\u2013like mutations which aligned with \u201cclassical papillary nucleus\u201d, papillary architecture, and conventional PTC outcomes, and RAS or RAS\u2013like mutations that were associated with \u201cpapillary\u2010like nucleus\u201d, follicular architecture, and follicular\u2010patterned neoplasm outcomes. The story has made full circle and the recent proposal to incorporate FVPTC into FC is in keeping with Lindsay\u2019s original concept. By our current understanding, these nuclei are classified better by molecular associations.<\/jats:p>","DOI":"10.1002\/cncy.70100","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:25:07Z","timestamp":1776875107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The fascinating history of papillary thyroid carcinoma nuclei: revelation of two nuclear morphologies\u2014\u201cClassical papillary\u201d and \u201cpapillary\u2010like\u201d, with different pathobiologic characteristics"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-0534","authenticated-orcid":false,"given":"N. 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