{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:05:08Z","timestamp":1791378308670,"version":"4.3.2"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recognition of high\u2010risk human papillomavirus (HPV) as the etiologic agent in nearly all cervical cancers has fundamentally reshaped screening strategies, driving the development and adoption of highly sensitive molecular HPV assays. Over the past several decades, cervical cancer screening guidelines have shifted from primarily cytology\u2010based approaches toward HPV\u2010based modalities, with primary HPV testing now recommended as the preferred method by the American Cancer Society and anticipated to be similarly endorsed by the United States Preventive Services Task Force. This article traces the evolution of cervical cancer screening, from the original Papanicolaou test to current guideline recommendations, and discusses the logistical requirements for transitioning to a primary HPV screening system, including triage strategies for HPV\u2010positive cases. The authors additionally present an institutional experience of initiating primary HPV testing, highlighting its impact on cytopathology laboratory workflow and specimen volumes.<\/jats:p>","DOI":"10.1002\/cncy.70129","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:24:37Z","timestamp":1784701477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Implementation and impact of primary HPV testing in cervical cancer screening: Historical perspectives and institutional experience at a large academic medical center"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-5625","authenticated-orcid":false,"given":"Rebecca A.","family":"Yoda","sequence":"first","affiliation":[{"name":"Division of Cytopathology, Department of Laboratory Medicine and Pathology University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8745-0025","authenticated-orcid":false,"given":"Eric C.","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cytopathology, Department of Laboratory Medicine and Pathology University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_15_3_1","article-title":"National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) Program","author":"National Cancer Institute","year":"2026","journal-title":"Cancer Stat Facts: Cervical Cancer"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70043"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7188.904"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7193.1244"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23276"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2011.3385"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/coc.0000000000000264"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.10.147"},{"key":"e_1_2_15_11_1","first-page":"528","volume-title":"3rd Race Betterment Conference","author":"Papanicolaou GN","year":"1928"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.51.2.92"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)40621-6"},{"key":"e_1_2_15_14_1","unstructured":"US Food and Drug Administration.Summary of Safety and Effectiveness Data \u2010 Digene Hybrid Capture 2 High\u2010Risk HPV DNA Test. 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