{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:22:45Z","timestamp":1791134565817,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,1,18]],"date-time":"2002-01-18T00:00:00Z","timestamp":1011312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2002,2,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multifunctional Ca<jats:sup>2+<\/jats:sup>\/calmodulin\u2010dependent protein kinase II (CaMKII) is highly enriched at synapses and has been implicated in regulating the formation and function of several sensory systems, including the visual and the somatosensory systems. Although there is evidence for CaMKII expression in the olfactory system, the cellular localization of CaMKII has not been well studied and its function remains unknown. In this study, we examined the normal expression patterns of the predominant \u03b1CaMKII in the mouse main olfactory bulb. We showed that \u03b1CaMKII expression levels were high in the olfactory bulb and were developmentally regulated. Immunoreactivity to \u03b1CaMKII was heavy in the external plexiform layer and the granule cell layer but minimal in the olfactory nerve layer and the glomerular layer. At the cellular level, \u03b1CaMKII was selectively expressed in the \u03b3\u2010aminobutyric acid (GABA)ergic granule cells but not in the GABAergic periglomerular cells. Unexpectedly, \u03b1CaMKII was not detected in the glutamatergic mitral\/tufted cells. At the ultrastructural level, \u03b1CaMKII immunoreactivity was positive in granule cell spines and dendrites, but negative in mitral\/tufted cell dendrites. In contrast, in the piriform cortex, as in the majority of cortical regions, \u03b1CaMKII was expressed in the glutamatergic neurons but not in the GABAergic neurons. Our results set the stage for ongoing investigations of the roles of CaMKII in the formation and function of the olfactory system. J. Comp. Neurol. 443:226\u2013236, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.10125","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:11:41Z","timestamp":1030313501000},"page":"226-236","source":"Crossref","is-referenced-by-count":45,"title":["Expression pattern of \u03b1CaMKII in the mouse main olfactory bulb"],"prefix":"10.1002","volume":"443","author":[{"given":"Dong\u2010Jing","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Greer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Firestein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1523\/JNEUROSCI.04-03-00638.1984","article-title":"Effects of sensory deprivation on the developing mouse olfactory system: a light and electron microscopic, morphometric analysis","volume":"4","author":"Benson TE","year":"1984","journal-title":"J Neurosci"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-06-01540.1991"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90188-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.57.030195.002221"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80647-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-12-03270.1985"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5352.870"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5260.421"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00164-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80181-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01206454"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902560208"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.61.070192.003015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.5.1536"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81013-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-02-00611.1994"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(85)90265-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.23.7357"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"RC19","DOI":"10.1523\/JNEUROSCI.19-14-j0005.1999","article-title":"Impaired odor adaptation in olfactory receptor neurons after inhibition of Ca(2+)\/calmodulin kinase II","volume":"19","author":"Leinders\u2010Zufall T","year":"1999","journal-title":"J Neurosci"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.21.8257"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81139-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/25.4.401"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.14.7332"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018549"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199808)36:2<221::AID-NEU9>3.0.CO;2-3"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/340554a0"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2549638"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90009-8"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.12.4781"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.49.31670"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-17-06790.1998"},{"key":"e_1_2_6_33_1","first-page":"159","volume-title":"The synaptic organization of the brain","author":"Shepherd GM","year":"1998"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1321493"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1378648"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00356-0"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80561-9"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5348.222"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00262-8"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81140-X"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80072-0"},{"key":"e_1_2_6_42_1","doi-asserted-by":"crossref","first-page":"8909","DOI":"10.1523\/JNEUROSCI.19-20-08909.1999","article-title":"Postsynaptic calcium\/calmodulin\u2010dependent protein kinase II is required to limit elaboration of presynaptic and postsynaptic neuronal arbors","volume":"19","author":"Zou DJ","year":"1999","journal-title":"J Neurosci"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.10125","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.10125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T01:50:57Z","timestamp":1696989057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.10125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,18]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,2,11]]}},"alternative-id":["10.1002\/cne.10125"],"URL":"https:\/\/doi.org\/10.1002\/cne.10125","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,18]]}}}