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However, comparable data are not available for the third order of amphibians, the limbless gymnophionans (caecilians). To further assess general and derived features of the cholinergic system in amphibians, we have investigated the distribution of choline acetyltransferase immunoreactive (ChAT\u2010ir) cell bodies and fibers in the brain of the gymnophionan <jats:italic>Dermophis mexicanus<\/jats:italic>. This distribution showed particular features of gymnophionans such as the existence of a particularly large cholinergic population in the striatum, the presence of ChAT\u2010ir cells in the mesencephalic tectum, and the organization of the cranial nerve motor nuclei. These peculiarities probably reflect major adaptations of gymnophionans to a fossorial habit. Comparison of our results with those in other vertebrates, including a segmental approach to correlate cell populations across species, shows that the general pattern of organization of cholinergic systems in vertebrates can be modified in certain species in response to adaptative processes that lead to morphological and behavioral modifications of members of a given class of vertebrates, as shown for gymnophionans. J. Comp. Neurol. 448:249\u2013267, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.10233","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:48:25Z","timestamp":1030319305000},"page":"249-267","source":"Crossref","is-referenced-by-count":29,"title":["Localization of choline acetyltransferase (ChAT) immunoreactivity in the brain of a caecilian amphibian, <i>Dermophis mexicanus<\/i> (Amphibia: Gymnophiona)"],"prefix":"10.1002","volume":"448","author":[{"given":"Agust\u00edn","family":"Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas 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