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Wild\u2010type (WT) and Y1R\u2010knockout (KO) mice were also analyzed. Y1R\u2010LI was found in small arteries and arterioles in many tissues, with particularly high levels in the thyroid and parathyroid glands. In the thyroid gland, Y1R\u2010LI was seen in blood vessel walls lacking \u03b1\u2010smooth muscle actin, i.e., perhaps in endothelial cells of capillaries. Larger arteries lacked detectable Y1R\u2010LI. A distinct Y1R\u2010immunoreactive (IR) reticulum was seen in the WT mouse spleen, but not in Y1R\u2010KO mouse or rat. In the gastrointestinal tract, Y1R\u2010positive neurons were observed in the myenteric plexus, and a few enteroendocrine cells were Y1R\u2010IR. Some cells in islets of Langerhans in the pancreas were Y1R\u2010positive, and double immunostaining showed coexistence with somatostatin in D\u2010cells. In the urogenital tract, Y1R\u2010LI was observed in the collecting tubule cells of the renal papillae and in some epithelial cells of the seminal vesicle. Some chromaffin cells of adrenal medulla were positive for Y1R. The problem of the specificity of the Y1R\u2010LI is evaluated using adsorption tests as well as comparisons among rat, WT mouse, and mouse with deleted Y1R. Our findings support many earlier studies based on other methodologies, showing that Y1Rs on smooth muscle cells of blood vessels mediate NPY\u2010induced vasoconstriction in various organs. In addition, Y1Rs in other cells in parenchymal tissues of several organs suggest nonvascular effects of NPY via the Y1R. J. Comp. Neurol. 449:390\u2013404, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.10303","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:33:49Z","timestamp":1030318429000},"page":"390-404","source":"Crossref","is-referenced-by-count":39,"title":["Distribution of neuropeptide Y Y1 receptors in rodent peripheral tissues"],"prefix":"10.1002","volume":"449","author":[{"given":"Hideki","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo R.","family":"Brumovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Kopp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Pedrazzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"H\u00f6kfelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/40.10.1527370"},{"key":"e_1_2_7_3_1","unstructured":"Ahr\u00e9nB.1981.On the peptidergic and aminergic regulation of insulin secretion. 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