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Increases in the number of TrkA\u2010immunoreactive (IR) cell profiles were detected in the L1 and L6 DRG (four\u2010fold; <jats:italic>P<\/jats:italic> \u2264 0.01) and the S1 DRG (1.5\u2010fold; <jats:italic>P<\/jats:italic> \u2264 0.05) but not in the L2, L4, and L5 DRG with CYP\u2010induced cystitis of acute and chronic duration compared with control rats. The number of TrkB\u2010IR cell profiles increased in the L1 and L2 DRG (L1: 2.6\u2010fold; L2: 1.4\u2010fold; <jats:italic>P<\/jats:italic> \u2264 0.05) and in the L6 and S1 DRG (L6: 2.2\u2010fold; S1: 1.3\u2010fold; <jats:italic>P<\/jats:italic> \u2264 0.05) only after acute CYP treatment (8 hours). After CYP treatment, the percentage of bladder afferent cell profiles expressing TrkA\u2010IR (\u223c50%; <jats:italic>P<\/jats:italic> \u2264 0.05) increased in L1 and L6 DRG. The percentage of bladder afferent cell profiles expressing TrkB\u2010IR (\u223c45%; <jats:italic>P<\/jats:italic> \u2264 0.05) in L1, L2, L6, and S1 DRG also increased compared with control cell profiles. The increase in TrkA\u2010IR in bladder afferent cells occurred 8 hours after CYP treatment and was maintained in L1 DRG with chronic (10 days) CYP\u2010induced cystitis. However, the increase in bladder afferent cells expressing TrkB\u2010IR only occurred at the most acute time point examined (8 hours). TrkA\u2010IR and TrkB\u2010IR cell profiles also demonstrated phosphorylated Trk\u2010IR with acute and\/or chronic CYP\u2010induced cystitis. These results demonstrated that CYP\u2010induced cystitis increases the expression and phosphorylation of Trk receptors in lumbosacral DRG. Expression of neurotrophic factors in the inflamed urinary bladder may contribute to this increased expression, and neurotrophic factor and Trk interactions may play unique roles in decreased urinary tract plasticity with CYP\u2010induced cystitis. J. Comp. Neurol. 454:200\u2013211, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.10447","type":"journal-article","created":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T14:15:20Z","timestamp":1036160120000},"page":"200-211","source":"Crossref","is-referenced-by-count":81,"title":["Cystitis\u2010induced upregulation of tyrosine kinase (TrkA, TrkB) receptor expression and phosphorylation in rat micturition pathways"],"prefix":"10.1002","volume":"454","author":[{"given":"Li\u2010Ya","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret 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