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By immunolabeling for the glial fibrillary acidic protein (GFAP), we show that a regular dentate radial glial scaffold fails to form in mutants deficient of Reelin, Dab1, and VLDLR and ApoER2. Mutant mice lacking only one of the Reelin receptors, VLDLR or ApoER2, display a gradual expression of the radial glial defects seen in mutants that lack both receptors. Our results suggest that Reelin signaling via ApoER2, VLDLR, and Dab1 is required for the formation of a regular radial glial scaffold in the dentate gyrus. J. Comp. Neurol. 460:56\u201365, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.10644","type":"journal-article","created":{"date-parts":[[2003,4,7]],"date-time":"2003-04-07T15:02:34Z","timestamp":1049727754000},"page":"56-65","source":"Crossref","is-referenced-by-count":85,"title":["Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2\/VLDLR\u2010deficient mice"],"prefix":"10.1002","volume":"460","author":[{"given":"Karl Heinz","family":"Weiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Johanssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Tielsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Herz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Deller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Frotscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckart","family":"F\u00f6rster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,4,3]]},"reference":[{"issue":"2","key":"e_1_2_6_2_1","first-page":"1","article-title":"Time of origin in the hippocampal region: an autoradiographic study in the mouse","author":"Angevine JB","year":"1965","journal-title":"Exp Neurol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/192766b0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01675-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901900107"},{"key":"e_1_2_6_6_1","first-page":"691","article-title":"The migration of neuroblasts in the developing cerebral cortex","volume":"99","author":"Berry M","year":"1965","journal-title":"J Anat"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901480202"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-6619-9_3"},{"key":"e_1_2_6_9_1","first-page":"103","volume-title":"Current topics in developmental biology. 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