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The nucleus rotundus is generally believed to contain internal divisions processing information on color, form, motion, and looming of visual objects. The detailed arrangement of these internal divisions is unclear. Here, we map the expression of four classic cadherins (N\u2010cadherin, R\u2010cadherin, cadherin\u20106B, and cadherin\u20107), which are markers for specific functional gray matter divisions and their fiber connections in the vertebrate brain. Results show that each cadherin is expressed by one coherent part of the nucleus rotundus that is connected to other brain structures by fiber tracts expressing the same subtype of cadherin. Overall, the expression of the four cadherins encompasses almost the entire nucleus rotundus. The four cadherin\u2010expressing parts show different degrees of overlap. For example, the cadherin\u20106B part and the cadherin\u20107 part overlap extensively, whereas the R\u2010cadherin part and the cadherin\u20106B part show little overlap and are partially complementary. Regions with shallow gradients of cadherin expression alternate with regions that show relatively abrupt changes in cadherin expression. At some points, changes of cadherin expression are also arranged in a pinwheel\u2010like fashion, alternating between clockwise and counterclockwise orientations. In general, these results are reminiscent of the organization of functional modules in the mammalian visual cortex. It is speculated that each domain of cadherin expression corresponds to a functional domain, which processes a specific stimulus feature. J. Comp. Neurol. 467:536\u2013548, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.10954","type":"journal-article","created":{"date-parts":[[2003,11,13]],"date-time":"2003-11-13T14:10:31Z","timestamp":1068732631000},"page":"536-548","source":"Crossref","is-referenced-by-count":15,"title":["Internal structure of the nucleus rotundus revealed by mapping cadherin expression in the embryonic chicken visual 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