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We observed striking changes in the developmental pattern of L1 expression between birth (P0) and adult ages, with intense L1\u2010immunopositive axons prevalent throughout the funiculi at P0 compared with predominantly L1\u2010immunonegative funicular axons in adults. At all ages and spinal levels examined, some L1\u2010positive dorsal root afferents entered the spinal cord, coursed in Lissauer's tract, and projected into the superficial dorsal horn and the dorsal columns, as well as across the dorsal commissure. Additional L1\u2010positive axons were detected consistently around the perimeter of the spinal cord, in the dorsolateral funiculus, and adjacent to the central canal. While specific L1\u2010labeled axons were detected at all ages, a pattern of segmental variation was observed within animals, with the highest levels of L1 expression detected in lumbar and sacral segments and the lowest in cervical spinal cord. The pattern of L1 immunoreactivity was compared to that of the growth\u2010associated protein GAP\u201043 and the results indicated colabeling of most axons. These observations demonstrate that L1 is expressed on immature axons well into postnatal development, possibly until they have completed their differentiation. Furthermore, the L1\u2010positive axons that continue to be detected in adults are likely to be either unmyelinated or sprouting axons. J. Comp. Neurol. 467:375\u2013388, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.10956","type":"journal-article","created":{"date-parts":[[2003,11,4]],"date-time":"2003-11-04T09:00:26Z","timestamp":1067936426000},"page":"375-388","source":"Crossref","is-referenced-by-count":22,"title":["Expression of L1 decreases during postnatal development of rat spinal cord"],"prefix":"10.1002","volume":"467","author":[{"given":"Alin","family":"Akopians","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve A.","family":"Runyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia 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