{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:27:08Z","timestamp":1790980028511,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,1,12]],"date-time":"2004-01-12T00:00:00Z","timestamp":1073865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2004,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several strains of mice hear well initially but show progressive sensorineural hearing loss. Affected cochlear cell types include all those known to be affected in human age\u2010related hearing loss (ARHL), or presbycusis. Thus these mice have been offered as models of human ARHL. At present, however, few mouse ARHL models are sufficiently well described to serve as the basis for specific hypotheses about human ARHL. We examined 1\u2010month\u2010old and 15\u2010month\u2010old 129S6\/SvEv (129S6) mice and compared them with BALB\/cJ and CBA\/J mice. Age\u2010related elevation of compound action potential thresholds was interpreted in the light of endocochlear potentials and changes in hair cells, afferent neurons, fibrocytes in spiral limbus and ligament, and supporting cells within the organ of Corti. Aging in 129S6 mice was associated with high\u2010frequency hearing loss. Four components of age\u2010related cochlear degeneration emerged from quantitative analyses, including 1) basal loss of outer hair cells; 2) basal loss of type IV fibrocytes in the spiral ligament; 3) apical loss of fibrocytes in spiral limbus, and 4) anomalies of supporting cells in the cochlear base. Although neuronal loss was not consistently found, two mice showed loss of afferent dendrites and cell bodies in the cochlear apex without inner hair cell loss. Despite multifaceted degeneration, hearing loss in 129S6 mice appears to be best explained by degenerative changes in outer hair cells and in the organ of Corti, conforming to human <jats:italic>sensory<\/jats:italic> ARHL. Age\u2010related changes in the apical spiral limbus may promote pathology of the medial organ of Corti and eventual loss of afferent neurons, with possible implications for human <jats:italic>neural<\/jats:italic> ARHL. J. Comp. Neurol. 469:377\u2013390, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.11011","type":"journal-article","created":{"date-parts":[[2004,1,13]],"date-time":"2004-01-13T12:00:37Z","timestamp":1073995237000},"page":"377-390","source":"Crossref","is-referenced-by-count":42,"title":["Cellular correlates of progressive hearing loss in 129S6\/SvEv mice"],"prefix":"10.1002","volume":"469","author":[{"given":"Kevin K.","family":"Ohlemiller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M.","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,1,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(96)00184-0"},{"key":"e_1_2_6_3_1","first-page":"283","volume-title":"New perspectives on noise\u2010induced hearing loss","author":"Bohne 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