{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:39:43Z","timestamp":1790836783665,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,1,23]],"date-time":"2004-01-23T00:00:00Z","timestamp":1074816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the role of primary afferent neurons in the somatosensory cortical \u201creactivation\u201d that occurs after a localized cervical dorsal root lesion (Darian\u2010Smith and Brown [2000] Nat. Neurosci. 3:476\u2013481). After section of the dorsal rootlets that enervate the macaque's thumb and index finger (segments C6\u2013C8), the cortical representation of these digits was initially silenced but then re\u2010emerged for these same digits over 2\u20134 postlesion months. Cortical reactivation was accompanied by the emergence of physiologically detectable input from these same digits within dorsal rootlets bordering the lesion site. We investigated whether central axonal sprouting of primary afferents spared by the rhizotomy could mediate this cortical reactivation. The cortical representation of the hand was mapped electrophysiologically 15\u201325 weeks after the dorsal rootlet section to define this reactivation. Cholera toxin subunit B conjugated to horseradish peroxidase was then injected into the thumb and index finger pads bilaterally to label the central terminals of any neurons that innervated these digits. Primary afferent terminal proliferation was assessed in the spinal dorsal horn and cuneate nucleus at 7 days and 15\u201325 postlesion weeks. Labeled terminal bouton distributions were reconstructed and the \u201clesion\u201d and control sides compared within each monkey. Distributions were significantly larger on the side of the lesion in the dorsal horn and cuneate nucleus at 15\u201325 weeks after the dorsal rootlet section, than those mapped only 7 days postlesion. Our results provide direct evidence for localized sprouting of spared (uninjured) primary afferent terminals in the dorsal horn and cuneate nucleus after a restricted dorsal root injury. J. Comp. Neurol. 470:134\u2013150, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.11030","type":"journal-article","created":{"date-parts":[[2004,1,26]],"date-time":"2004-01-26T08:02:01Z","timestamp":1075104121000},"page":"134-150","source":"Crossref","is-referenced-by-count":52,"title":["Primary afferent terminal sprouting after a cervical dorsal rootlet section in the macaque 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