{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:28:14Z","timestamp":1787887694831,"version":"build-2784847793"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,4,20]],"date-time":"2001-04-20T00:00:00Z","timestamp":987724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2001,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The transition metal zinc is an essential dietary constituent that is believed to serve an important intercellular signaling role at certain excitatory synapses in the central nervous system. In the present study, we used histochemical techniques to investigate the distribution of synaptic zinc during postnatal development of retinogeniculate projections in rats. From postnatal day (P) 1 until P\u201021, the pattern of zinc histochemical staining in the dorsal lateral geniculate nucleus (LGNd) precisely matched the distribution of axon terminals from the ipsilateral eye that were labeled by anterograde transport of horseradish peroxidase. Regions of the LGNd that contained only crossed axons were devoid of zinc staining. Abnormalities in the distribution of uncrossed retinogeniculate projections in albino versus pigmented rats were paralleled by identical variations in localization of synaptic zinc. Unilateral enucleation on P\u201010 was followed within 5 days by loss of zinc staining in the LGNd ipsilateral to the removed eye without affecting staining in the contralateral nucleus. Finally, the ability to detect zinc histochemically in the LGNd ceased at approximately P\u201024. These findings provide evidence that zinc is sequestered within synaptic boutons of a subpopulation of retinal ganglion cells whose axons terminate on the ipsilateral side of the brain. The duration of zinc staining overlaps with the major period of axonal remodeling in the LGNd, suggesting that synaptically released zinc may play a role in postnatal refinement of retinogeniculate projections. J. Comp. Neurol. 433:515\u2013525, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.1157","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:23:10Z","timestamp":1030306990000},"page":"515-525","source":"Crossref","is-referenced-by-count":18,"title":["Transient expression of synaptic zinc during development of uncrossed retinogeniculate projections"],"prefix":"10.1002","volume":"433","author":[{"given":"Peter 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