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In the present investigation, we examined whether subclasses of serotonergic RM and NRMC cells can be delineated based on their response to a visceral stimulus, and whether any such subclasses are morphologically distinct. Most RM and NRMC serotonergic cells tested (81 of 116) responded to retraction of the descending aorta into a polyethylene tube (the snare stimulus) with 57% of all cells tested excited and 13% inhibited. Responses of serotonergic cells to the snare outlasted the stimulus, were not reflective of evoked cardiovascular changes, and were observed in sino\u2010aortic deafferented rats, evidence that the snare stimulus does not influence serotonergic cell discharge through activation of baroreceptors. Because serotonergic cells responsive to the snare were also responsive to mechanical brushing within the retroperitoneum, the snare is likely to change serotonergic cell discharge by means of the activation of mechanosensitive visceral afferents. Intracellular labeling of physiologically characterized serotonergic RM and NRMC cells showed that cells that were responsive to the snare stimulus had simpler axonal collateralization patterns than cells that were unresponsive to the snare stimulus. This association between morphological and physiological properties provides additional evidence that subpopulations of serotonergic cells exist and serve varied physiological functions. J. Comp. Neurol. 439:426\u2013439, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.1360","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:26:02Z","timestamp":1030310762000},"page":"426-439","source":"Crossref","is-referenced-by-count":37,"title":["Physiological and anatomic evidence for functional subclasses of serotonergic raphe magnus cells"],"prefix":"10.1002","volume":"439","author":[{"given":"Keming","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,10,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1523\/JNEUROSCI.02-12-01786.1982","article-title":"Intracellular identification of central noradrenergic and serotonergic neurons by a new double 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