{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:41:20Z","timestamp":1776472880753,"version":"3.51.2"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,10,2]],"date-time":"2001-10-02T00:00:00Z","timestamp":1001980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2001,10,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurons in the inner nuclear layer (INL) of the vertebrate retina undergo considerable programmed cell death during development, but the determinants of this cell death remain largely unknown. The present study examines the role of retinal ganglion cells in support of INL neurons in the developing ferret retina. The retinal ganglion cell population was eliminated by optic nerve transection at postnatal day (P) 2, and the incidence of cell death was examined using terminal deoxytransferase dUTP nick\u2010end labelling (TUNEL) at various ages during the first 3 postnatal weeks. Significant increases in TUNEL\u2010positive cells were observed in the neuroblast layer (NBL) as early as P3, prior to synapse formation within the inner plexiform layer (IPL), and again in the INL at P22, the normal peak of naturally occurring cell death within the ferret's INL. A decrease in TUNEL\u2010positive cells was found in the NBL at P8. These results show three phases of response to the loss of retinal ganglion cells and suggest that cells in the NBL\/INL are normally dependent on retinal ganglion cells for their survival. Recent studies have shown that certain populations of retinal neurons are reduced in adult animals that had lost the population of ganglion cells during early development, so the present study also examined when this reduction could first be detected. The number of parvalbumin\u2010immunoreactive amacrine cells was decreased significantly in the NBL of the manipulated eye as early as P8, when we could first label this population, and this difference persisted through adulthood. The fact that cell death in the NBL has already increased within 24 hours of ganglion cell elimination, coupled with the specificity of this effect on the adult complement of INL cell types, shows that cell\u2013cell interactions controlling survival are already highly specific for particular types of retinal neuron early in development J. Comp. Neurol. 439:440\u2013449, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.1361","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:26:02Z","timestamp":1030310762000},"page":"440-449","source":"Crossref","is-referenced-by-count":23,"title":["Two phases of increased cell death in the inner retina following early elimination of the ganglion cell population"],"prefix":"10.1002","volume":"439","author":[{"given":"Karen","family":"Cusato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie B.","family":"Stagg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin 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