{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:20:31Z","timestamp":1760707231103},"reference-count":88,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,29]],"date-time":"2004-03-29T00:00:00Z","timestamp":1080518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2004,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During development, the axons of olfactory receptor neurons project to the CNS and converge on glomerular targets. For vertebrate and invertebrate olfactory systems, neuron\u2013glia interactions have been hypothesized to regulate the sorting and targeting of olfactory receptor axons and the development of glomeruli. In the moth <jats:italic>Manduca sexta<\/jats:italic>, glial reduction experiments have directly implicated two types of central olfactory glia, the sorting zone\u2010 and neuropil\u2010associated glia, in key events in olfactory development, including axon sorting and glomerulus stabilization. By using cocultures containing central olfactory glial cells and explants of olfactory receptor epithelium, we show that olfactory receptor growth cones elaborate extensively and cease advancement following contact with sorting zone\u2010 and neuropil\u2010associated glial cells. These effects on growth cone behavior were specific to central olfactory glia; peripheral glial cells of the olfactory nerve failed to elicit similar responses in olfactory receptor growth cones. We propose that sorting zone\u2010 and neuropil\u2010associated glial cells similarly modify axon behavior in vitro by altering the adhesive properties and cytoskeleton of olfactory receptor growth cones and that these in vitro changes may underlie functionally relevant changes in growth cone behavior in vivo. J. Comp. Neurol. 472:478\u2013495, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20058","type":"journal-article","created":{"date-parts":[[2004,3,29]],"date-time":"2004-03-29T22:01:09Z","timestamp":1080597669000},"page":"478-495","source":"Crossref","is-referenced-by-count":14,"title":["In vitro analyses of interactions between olfactory receptor growth cones and glial cells that mediate axon sorting and glomerulus formation"],"prefix":"10.1002","volume":"472","author":[{"given":"Eric S.","family":"Tucker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne A.","family":"Oland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie P.","family":"Tolbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200011000-00006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960909)373:1<118::AID-CNE10>3.0.CO;2-G"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-08-03033.2002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81093-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4695(200012)45:4<195::AID-NEU1>3.0.CO;2-Y"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-20-08894.1999"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00180-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902850407"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903120311"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(97)00041-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90425-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1412"},{"key":"e_1_2_6_14_1","volume-title":"Statistical methods for research workers","author":"Fischer RA","year":"1925"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/77680"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.1050"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960226)366:1<1::AID-CNE1>3.0.CO;2-7"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1523\/JNEUROSCI.14-10-06121.1994","article-title":"Axon\u2013glia interactions regulate ECM patterning in the postnatal rat olfactory bulb","volume":"14","author":"Gonzalez ML","year":"1994","journal-title":"J Neurosci"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(02)00323-9"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0583"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.20.1.595"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/scdb.1996.0139"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00453-6"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-07-02589.1999"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(19990115)25:2<99::AID-GLIA1>3.0.CO;2-V"},{"key":"e_1_2_6_26_1","unstructured":"KentK.1985.Metamorphosis of the antennal center and the influence of sensory innervation on the formation of glomeruli in the hawkmothManduca sexta. 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