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Nightly treatment with an augmented acoustic environment (AAE)\u201412\u2010hour periods of exposure to repetitive noise bursts of moderate intensity, begun at age 25 days\u2014resulted in less severe hearing loss compared with control mice. Cochlear histopathological correlates of AAE treatment, assessed at 12\u201314 months of age, included lessened severity of progressive loss of outer hair cells in both sexes as well as small savings of spiral ganglion cells in females and inner hair cells in males. AAE effects on the number of surviving neurons (age 12\u201314 months) in the anterior ventral cochlear nucleus (AVCN) depended on sex. Compared with controls, the loss of AVCN neurons that typically accompanies the initial period of hearing loss (between 2 and 7 months of age) was not significantly affected by AAE treatment in females. In contrast, males treated with the AAE exhibited more severe loss of neurons in the dorsal and ventral extremes of the AVCN than male controls of the same age. AAE treatment begun at age 3\u20135 months resulted in significant but less severe loss of AVCN neurons in 1\u2010year\u2010old male mice. J. Comp. Neurol. 472:358\u2013370, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20065","type":"journal-article","created":{"date-parts":[[2004,3,26]],"date-time":"2004-03-26T21:01:27Z","timestamp":1080334887000},"page":"358-370","source":"Crossref","is-referenced-by-count":43,"title":["Effects of prolonged exposure to an augmented acoustic environment on the auditory system of middle\u2010aged C57BL\/6J mice: Cochlear and central histology and sex differences"],"prefix":"10.1002","volume":"472","author":[{"given":"James F.","family":"Willott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Bross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/00042192-200007030-00008","article-title":"Auditory 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