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The distribution pattern of the 5\u2010HT markers was heterogeneous, with variable densities of binding of each observed both in nuclei with and without 5\u2010HT cell bodies. The highest density of binding for each marker was observed in the raph\u00e9 nuclei, the site of the highest density of 5\u2010HT cell bodies. A significant reduction in 5\u2010HT receptor binding measured with <jats:sup>3<\/jats:sup>H\u2010LSD was observed between midgestation and infancy, and between infancy and maturity in multiple nuclei, but no changes were observed across infancy. A significant increase in 5\u2010HT<jats:sub>1A<\/jats:sub> receptor binding density was observed across infancy in the hypoglossal nucleus (regression slope coefficient = 0.008 \u00b1 0.002, <jats:italic>P<\/jats:italic> = 0.02), and a marginally significant increase was observed in the raph\u00e9 obscurus (regression slope coefficient = 0.061 \u00b1 0.026 [mean \u00b1 SEM], <jats:italic>P<\/jats:italic> = 0.05). No significant age\u2010related changes in SERT binding were observed at any time. With the exception of the hypoglossal nucleus, where 5\u2010HT<jats:sub>1A<\/jats:sub> receptor binding increases while SERT binding remains stable, the medullary 5\u2010HT markers analyzed in the study are essentially \u201cin place\u201d at birth. This study provides important baseline data that serve as a foundation for future work in pediatric 5\u2010HT brainstem disorders, including sudden infant death syndrome. J. Comp. 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