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From 8\u201313 g.w. mainly CaBP was expressed in the cells while fiber bundles traversing the thalamus in addition to CaBP expressed all GABA markers except GAD67. CaBP and PARV expression patterns in different nuclei changed over the time course studied, whereas NT was expressed consistently along the anterior\u2010lateral curvature of the thalamus. CalR and SMI were detectable at 23 g.w. in the ventral parts of the dorsal thalamus. Most remarkably, punctate GAD65 immunoreactivity in the neuropil was confined to the nigro\u2010 and pallidothalamic afferent receiving nuclei from 16 to about 21 g.w., overlapping with that of CaBP in some of these nuclei (subdivisions of the ventral anterior and mediodorsal nuclei) and with PARV in others (centromedian nucleus). During this period, GAD65 immunoreactivity can be considered a marker of the basal ganglia afferent receiving territory in the motor thalamus. GAD67\u2010positive local circuit neurons were first detected at 12\u201313 g.w. in the thalamic nuclei outside the basal ganglia afferent receiving territory. In the ventral anterior and centromedian nuclei, GAD\u2010containing local circuit neurons were not conspicuous even at 22\u201323 g.w. The cells of the reticular nucleus expressed GAD67 and PARV from 12 g.w. on starting in the lateral\u2010posterior regions. By 23 g.w., both markers were expressed in about two\u2010thirds of the nucleus except for its most medial\u2010anterior part. The results imply spatially and temporally differential expression of GABA and differentiation markers in the developing human thalamus. J. Comp. Neurol. 476:267\u2013289, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20216","type":"journal-article","created":{"date-parts":[[2004,7,16]],"date-time":"2004-07-16T21:06:57Z","timestamp":1090012017000},"page":"267-289","source":"Crossref","is-referenced-by-count":13,"title":["Development of the human motor\u2010related thalamic nuclei during the first half of gestation, with special emphasis on GABAergic circuits"],"prefix":"10.1002","volume":"476","author":[{"given":"Kristy","family":"Kultas\u2010Ilinsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Fallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Verney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901880308"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902750306"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90086-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(96)00107-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF02284802","article-title":"Neuronal and synaptic organization of the centromedian nucleus of the monkey thalamus: a quantitative ultrastructural study with tract tracing and immunohistochemical observations","volume":"25","author":"Ballercia G","year":"1996","journal-title":"J Neurocytol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"21098","DOI":"10.1016\/S0021-9258(19)36802-4","article-title":"Molecular heterogeneity of the gamma\u2010aminobutyric acid (GABA) transport system. 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