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To address these issues, we examined the distribution of TRPV1\u2010positive neurons in the trigeminal ganglion (TG) and trigeminal sensory nuclei principalis (Vp), oralis (Vo), interpolaris (Vi), and caudalis (Vc) in the rat via light and electron microscopy. In addition, we studied the colocalization of TRPV1\u2010positive neurons with substance P (SP) and calcitonin gene\u2010related peptide (CGRP) via confocal microscopy. In TG, only small and medium\u2010sized neurons were immunopositive for TRPV1. The staining for TRPV1 was found in axon collaterals in the dorsal parts of Vp, Vo, and Vi and in terminals and fibers throughout lamina I and the outer zone of lamina II (IIo) of Vc. With electron microscopy, TRPV1\u2010positive fibers in the ascending and descending trigeminal tracts were found to be unmyelinated. Almost all TRPV1\u2010positive terminals in Vc contained numerous large dense\u2010core vesicles and formed synaptic contacts with single small dendrites. Multiple immunofluorescence revealed a high degree of colocalization of TRPV1 with SP and CGRP in TG neurons as well as in fibers and terminals confined to laminae I and IIo of Vc. These results suggest that the central projections of unmyelinated (C) afferents sensitive to noxious heat and capsaicin are organized differently between Vc and the rostral trigeminal nuclei and that Vc may play a role in the development of hyperalgesia. J. Comp. Neurol. 478:62\u201371, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20272","type":"journal-article","created":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T19:15:40Z","timestamp":1093029340000},"page":"62-71","source":"Crossref","is-referenced-by-count":114,"title":["Expression of vanilloid receptor TRPV1 in the rat trigeminal sensory nuclei"],"prefix":"10.1002","volume":"478","author":[{"given":"Yong Chul","family":"Bae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Min","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Jin","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Shigenaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli G.","family":"Valtschanoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,8,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02380-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902830207"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-08-02901.1992"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1986.55.2.227"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90880-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91588-J"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903480107"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(20000313)418:3<299::AID-CNE5>3.0.CO;2-I"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1976.39.6.1160"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00221-002-1308-1","article-title":"Activation of brain stem neurons by irritant chemical stimulation of the throat assessed by c\u2010fos immunohistochemistry","volume":"148","author":"Boucher Y","year":"2003","journal-title":"Exp Brain Res"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.2.465"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.487"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/18906"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5464.306"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91096-7"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(89)90147-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1523\/JNEUROSCI.18-10-03529.1998","article-title":"Morphine administered in the substantia gelatinosa of the spinal trigeminal nucleus caudalis inhibits nociceptive activities in the spinal trigeminal nucleus oralis","volume":"18","author":"Dallel R","year":"1998","journal-title":"J Neurosci"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00503.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01665.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1948.01240020174015"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00475-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2535\/ofaj1936.76.1_33","article-title":"FRAP\u2010positive and capsaicin\u2010sensitive terminals in the substantia gelatinosa of the mouse spinal trigeminal nucleus caudalis","volume":"76","author":"Hiura A","year":"1999","journal-title":"Okajimas Fol Anat Jpn"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1152\/jn.1981.46.3.409","article-title":"Neuronal activity in medullary dorsal horn of awake monkeys trained in a thermal discrimination task. 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