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The neuroanatomical distribution of \u03f5\u2010sarcoglycan\u2010like immunoreactivity in mouse was investigated by using an antiserum against the \u03f5\u2010sarcoglycan protein. The expression of \u03f5\u2010sarcoglycan mRNA was studied by a sensitive fluorescence in situ hybridization (FISH) method. Immunohistochemistry and FISH revealed a wide distribution of \u03f5\u2010sarcoglycan protein and mRNA throughout the mouse brain. High expression levels of \u03f5\u2010sarcoglycan mRNA and immunoreactivity were found in the mitral cell layer of the olfactory bulb, the Purkinje cell layer in cerebellum, and the monoaminergic neurons in the mouse midbrain. Immunohistochemistry revealed a similar distribution of \u03f5\u2010sarcoglycan protein. Double\u2010labeling FISH showed colocalization of tyrosine hydroxylase and \u03f5\u2010sarcoglycan mRNAs within all the midbrain dopaminergic (DAergic) cell groups. By combining FISH with fluorescence immunohistochemistry, coexpression of \u03f5\u2010sarcoglycan mRNA and tryptophan hydroxylase immunoreactivity was found in the serotonergic (5\u2010HTergic) neurons within the dorsal raphe nucleus. The distribution of \u03f5\u2010sarcoglycan in the mouse brain suggests that the symptom complex of M\u2010D may be related to the effects of decreased \u03f5\u2010sarcoglycan activity on the development or function of monoaminergic neurons. J. Comp. Neurol. 482:50\u201373, 2005. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20377","type":"journal-article","created":{"date-parts":[[2004,12,20]],"date-time":"2004-12-20T17:42:28Z","timestamp":1103564548000},"page":"50-73","source":"Crossref","is-referenced-by-count":47,"title":["\u03f5\u2010Sarcoglycan immunoreactivity and mRNA expression in mouse brain"],"prefix":"10.1002","volume":"482","author":[{"given":"Pokman","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Gonzalez\u2010Maeso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Ruf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick R.","family":"Hof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart C.","family":"Sealfon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200101)49:1<121::AID-ANA20>3.0.CO;2-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10325"},{"key":"e_1_2_6_4_1","first-page":"199","article-title":"Toxins, genetics, and Parkinson's disease: the role of N\u2010acetyltransferase 2","volume":"80","author":"Bandmann O","year":"1999","journal-title":"Adv Neurol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(03)00047-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00748-0"},{"key":"e_1_2_6_7_1","first-page":"214","article-title":"Noval mutation (Y184C) in exon 4 of the beta\u2010sarcoglycan gene identified in a Portuguese patient. 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