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This study examined the effects of acute SCI (48 hours, 2 weeks) on TrkA and TrkB expression and phosphorylation, and CREB and c\u2010Jun expression in DRG. A significant increase in the number of TrkA\u2010 (1.5\u20133\u2010fold; <jats:italic>P<\/jats:italic> \u2264 0.05), TrkB\u2010 (1.3\u20132.0\u2010fold; <jats:italic>P<\/jats:italic> \u2264 0.05), and phosphorylated Trk (pTrk)\u2010immunoreactive (1.5\u20133\u2010fold; <jats:italic>P<\/jats:italic> \u2264 0.05) cells was observed in the L1, L6, and S1 DRG 48 hours, 2, or 6 weeks after SCI. A significant increase in the number of phosphorylated (p\u2010) CREB\u2010immunoreactive cells was observed in the L1, L2, L6, and S1 DRG 48 hours, 2, or 6 weeks after SCI. The largest changes in p\u2010CREB\u2010immunoreactivity were in L1 and L2 DRG (10\u2010fold; <jats:italic>P<\/jats:italic> \u2264 0.01) at 48 hours after SCI; however, changes were modest in bladder afferent neurons. After SCI, the overall number of c\u2010Jun\u2010immunoreactive cells in L1, L2, and S1 DRG was dramatically increased (3\u201310\u2010fold; <jats:italic>P<\/jats:italic> \u2264 0.01); however, only a low percentage of bladder afferent cells expressed c\u2010Jun\u2010IR before or after SCI. In summary, these results suggest that TrkA or TrkB may be involved in reorganization of micturition pathways after SCI. However, CREB or c\u2010Jun may not be downstream transcription factors in Trk\u2010mediated signaling cascades in micturition reflex pathways after SCI but may play a role in other, nonbladder SCI\u2010induced changes. J. Comp. Neurol. 482:142\u2013154, 2005. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20394","type":"journal-article","created":{"date-parts":[[2004,12,20]],"date-time":"2004-12-20T21:56:17Z","timestamp":1103579777000},"page":"142-154","source":"Crossref","is-referenced-by-count":35,"title":["Spinal cord injury\u2010induced expression of TrkA, TrkB, phosphorylated CREB, and c\u2010Jun in rat lumbosacral dorsal root ganglia"],"prefix":"10.1002","volume":"482","author":[{"given":"Li\u2010Ya","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret 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