{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:16:54Z","timestamp":1791173814723,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T00:00:00Z","timestamp":1121385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2005,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periglomerular cells (PG) are interneurons of the olfactory bulb (OB) that modulate the first synaptic relay of the olfactory information from the olfactory nerve to the dendrites of the bulbar principal cells. Previous investigations have pointed to the heterogeneity of these interneurons and have demonstrated the presence of two different types of PG. In the rat OB, type 1 PG receive synaptic contacts from the olfactory axons and are \u03b3\u2010aminobutyric acid (GABA)\u2010ergic, whereas type 2 PG do not receive synaptic contacts from the olfactory axons and are GABA immunonegative. In this study, we analyze and characterize neurochemically a group of PG that has not been previously classified either as type 1 or type 2. These PG are immunoreactive for the neuropeptides somatostatin (SOM) or cholecystokinin (CCK). By using double immunocytochemistry, we demonstrate that neither the SOM\u2010 nor the CCK\u2010immunoreactive PG contain GABA immunoreactivity, which is a neurochemical feature of type 1 PG. Moreover, they do not contain the calcium\u2010binding proteins calbindin D\u201028k and calretinin, which are neurochemical markers of the type 2 PG. Electron microscopy demonstrates that the dendrites of the SOM\u2010 and CCK\u2010containing PG are distributed in the synaptic and sensory subcompartments of the glomerular neuropil and receive synaptic contacts from the olfactory axons. Therefore, they should be included in the type 1 group rather than in the type 2. Altogether, these data indicate that the SOM\u2010 and the CCK\u2010containing PG may constitute a group of GABA\u2010immunonegative type 1 PG that has not been previously described. These results further extend the high degree of complexity of the glomerular circuitry. J. Comp. Neurol. 489:467\u2013479, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20649","type":"journal-article","created":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T17:18:31Z","timestamp":1121447911000},"page":"467-479","source":"Crossref","is-referenced-by-count":37,"title":["Characterization of somatostatin\u2010 and cholecystokinin\u2010immunoreactive periglomerular cells in the rat olfactory bulb"],"prefix":"10.1002","volume":"489","author":[{"given":"Mar\u00eda","family":"Guti\u00e8rrez\u2010Mecinas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Crespo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Blasco\u2010Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco 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