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Here, we show that ADAM21, but not ADAM2, \u20103, \u20109, \u201010, \u201012, \u201015, or \u201017, is expressed in adult rats and mice by ependyma and SVZ cells with long basal processes, and in radial glia at early postnatal times. ADAM21\u2010positive processes projected into the RMS, contacted blood vessels, and were present within the RMS intermingled with neuroblasts up to where neuroblasts start their radial migration and differentiation in the olfactory bulb. Tissue inhibitors of metalloproteases (TIMPs) 1, 2, and 3 are present in the ependymal layer but not in the SVZ and RMS. Thus, ADAM21 could regulate neurogenesis and guide neuroblast migration through cleavage\u2010dependent activation of proteins and integrin binding. ADAM21 is also present in growing axonal tracts during postnatal development and in growing primary olfactory axons in adults. In the olfactory nerve layer, ADAM21 often, but not always, colocalizes with OMP, a marker of mature olfactory neurons, but is not colocalized with the immature marker \u03b2III\u2010tubulin. This suggests that ADAM21 is involved in the final axonal outgrowth phase and\/or synapse formation. TIMP3 is present in periglomerular neurons, where it could restrict ADAM21\u2010mediated axonal growth to the glomeruli. ADAM21's unique disintegrin and metalloprotease sequences and its restricted expression suggest that it might be a good target for influencing neurogenesis and neuronal plasticity. J. Comp. Neurol. 490:163\u2013179, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20659","type":"journal-article","created":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T18:05:44Z","timestamp":1122573944000},"page":"163-179","source":"Crossref","is-referenced-by-count":52,"title":["A disintegrin and metalloprotease 21 (ADAM21) is associated with neurogenesis and axonal growth in developing and adult rodent CNS"],"prefix":"10.1002","volume":"490","author":[{"given":"Peng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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