{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:57:49Z","timestamp":1761742669055},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T00:00:00Z","timestamp":1130371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2005,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Diagnostic and Statistical Manual (DSM)\u2010IV definition of premature ejaculation is not based on evidence\u2010based studies. In particular, the absence of a well\u2010defined quantitative measure of the intravaginal ejaculation latency time (IELT) makes the DSM definition inadequate. Therefore, the DSM\u2010IV definition should be replaced by a medical definition that incorporates both quantitative as qualitative parameters of premature ejaculation. An evidence\u2010based medical definition should include a cutoff point of the IELT at the 0.5 and 2.5 percentiles of the IELT distribution in the general male population. Such a definition has recently been proposed on the basis of a stopwatch study of the IELT in 491 men from five different countries. Similarly, a cutoff point of ejaculation frequency in laboratory rats enhances the probability to distinguish genuine rapid\u2010ejaculator rats. Only by the strict application of these cutoff points is the probability enhanced that human and animal neurobiological research can prove whether these sexual endophenotypes differ in brain activation, have particular genetic genotypes (polymorphisms), are strictly under genetic control, or are dependent on environmental conditions and\/or genotypic\/environmental interactions. J. Comp. Neurol. 493:46\u201350, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20718","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T22:46:41Z","timestamp":1130453201000},"page":"46-50","source":"Crossref","is-referenced-by-count":12,"title":["Relevance of an evidence\u2010based ejaculation time cutoff point for neurobiological research of premature ejaculation"],"prefix":"10.1002","volume":"493","author":[{"given":"Marcel D.","family":"Waldinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(81)90023-X"},{"key":"e_1_2_10_3_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"APA (American Psychiatric Association)","year":"1994"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(69)90004-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(89)90128-8"},{"key":"e_1_2_10_6_1","first-page":"92","volume-title":"Human sexual inadequacy","author":"Masters WH","year":"1970"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(98)00015-7"},{"key":"e_1_2_10_8_1","volume-title":"Statistical methods in diagnostic medicine. Wiley Series in Probability and Statistics","author":"Obuchowski NA","year":"2002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199807006-00003"},{"key":"e_1_2_10_10_1","article-title":"Psycho\u2010pharmacology of male rat sexual behavior: modeling human sexual dysfunctions?","author":"Olivier B","year":"2005","journal-title":"Int J Impot Res"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.20353.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04252.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00413-0"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64146-8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.04495.x"},{"key":"e_1_2_10_16_1","first-page":"117","volume-title":"Advances in preclinical and clinical psychiatry","author":"Waldinger MD","year":"2000"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-004-0493-x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.9.1377"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)00183-6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/13651509809115376"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901172"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.20112.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.00070.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.00069.x"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.20718","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.20718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T02:13:37Z","timestamp":1694657617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.20718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,27]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,12,5]]}},"alternative-id":["10.1002\/cne.20718"],"URL":"https:\/\/doi.org\/10.1002\/cne.20718","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,27]]}}}