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The dorsolateral PAG is thought to be associated with aversive behaviors, but it is not yet understood how these behaviors are brought about. To elucidate the function of the PAG further, in the present study we investigated which brainstem regions project to the dorsolateral PAG. Wheat germ agglutinin\u2010horseradish peroxidase (WGA\u2010HRP) injections involving the dorsolateral PAG, but extending into the lateral part, resulted in many retrogradely labeled cells in the pontine and medullary tegmentum bilaterally. However, it was concluded that these neurons were labeled from the lateral PAG, because no anterograde labeling was found in the dorsolateral PAG after a large injection into the tegmentum. Retrogradely labeled cells were also found in the nucleus prepositus hypoglossi (PPH), mainly contralaterally. Injections of [<jats:sup>3<\/jats:sup>H]leucine or WGA\u2010HRP in the PPH resulted in anterogradely labeled fibers in the dorsolateral PAG. Two separate distribution patterns were found. The caudal and intermediate PPH projected to a small region on the dorsolateral edge of the dorsolateral column, whereas the supragenual PPH distributed labeled fibers to all other parts of the dorsolateral PAG, except the area on the dorsolateral edge. These separate PPH projections suggest that two subdivisions exist within the dorsolateral PAG. The present findings suggest a role for the dorsolateral PAG in the oculomotor system. J. Comp. Neurol. 492:303\u2013322, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20728","type":"journal-article","created":{"date-parts":[[2005,10,10]],"date-time":"2005-10-10T20:47:51Z","timestamp":1128977271000},"page":"303-322","source":"Crossref","is-referenced-by-count":18,"title":["Two parts of the nucleus prepositus hypoglossi project to two different subdivisions of the dorsolateral periaqueductal gray in cat"],"prefix":"10.1002","volume":"492","author":[{"given":"Esther Marije","family":"Klop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonora J.","family":"Mouton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ehling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Holstege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901810405"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981130)401:4<455::AID-CNE3>3.0.CO;2-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90062-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-1-4615-3302-3_11","volume-title":"The midbrain periaqueductal gray matter: functional, anatomical, and neurochemical organization","author":"Bandler R","year":"1991"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90047-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90041-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3302-3_1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00449-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000108)429:2<337::AID-CNE12>3.0.CO;2-Z"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(82)90009-0"},{"key":"e_1_2_6_12_1","volume-title":"The brainstem of the cat: A cytoarchitectonic atlas with stereotaxic coordinates","author":"Berman AL","year":"1968"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00318730"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236639"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61861-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902180303"},{"key":"e_1_2_6_17_1","first-page":"151","article-title":"Observations on the projection from the perihypoglossal nuclei onto the cerebellum in the macaque monkey","volume":"121","author":"Brodal A","year":"1983","journal-title":"Arch Ital Biol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990524)408:1<23::AID-CNE3>3.0.CO;2-J"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903480103"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(93)90088-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/B978-012547626-3\/50013-2","volume-title":"The human nervous sytem","author":"Carrive P","year":"2004"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199411000-00013"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199201000-00026"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90356-9"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/PL00005655","article-title":"Topographical characteristics of preposito\u2010collicular projections in the cat as revealed by Phaseolus vulgaris\u2010leucoagglutinin technique. 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