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Temporal lobe changes, as in hypergraphia, often increase idea generation, sometimes at the expense of quality. Frontal lobe deficits may decrease idea generation, in part because of rigid judgments about an idea's worth. These phenomena are clearest in verbal creativity, and roughly parallel the pressured communication of temporal lobe epilepsy, mania, and Wernicke's aphasia\u2014compared to the sparse speech and cognitive inflexibility of depression, Broca's aphasia, and other frontal lobe lesions. The phenomena also shape non\u2010linguistic creativity, as in that of frontotemporal dementia. The appropriate balance between frontal and temporal activity is mediated by mutually inhibitory corticocortical interactions. Mesolimbic dopamine influences novelty seeking and creative drive. Dopamine agonists and antagonists have opposite effects on goal\u2010directed behavior and hallucinations. Creative drive is not identical to skill\u2014the latter depends more on neocortical association areas. However, drive correlates better with successful creative output than skill does. Traditional neuroscientific models of creativity, such as the left brain \u2013 right brain hemispheric model, emphasize skills primarily, and stress art and musical skill at the expense of language and mathematics. The three\u2010factor model proposed here predicts findings in a broad range of normal and pathological states and can be tested in many experimental paradigms. J. Comp. Neurol. 493:147\u2013153, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20768","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T22:17:23Z","timestamp":1130451443000},"page":"147-153","source":"Crossref","is-referenced-by-count":245,"title":["Frontotemporal and dopaminergic control of idea generation and creative drive"],"prefix":"10.1002","volume":"493","author":[{"given":"Alice W.","family":"Flaherty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00491-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.10.1288"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(98)00028-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(18)30481-7"},{"key":"e_1_2_6_6_1","first-page":"35","article-title":"Mania, pseudomania, depression, and pseudodepression resulting from focal unilateral cortical lesions","volume":"12","author":"Braun CM","year":"1999","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-934X(03)00402-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00303-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.508"},{"key":"e_1_2_6_10_1","first-page":"8","article-title":"Neural circuitry of anxiety: evidence from structural and functional neuroimaging studies","volume":"37","author":"Cannistraro PA","year":"2003","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(99)00128-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.85.3.499"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15326934crj1701_4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.146.8.983"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/02783190009554069"},{"key":"e_1_2_6_16_1","first-page":"313","volume-title":"Handbook of creativity","author":"Csikszentmihalyi M","year":"1999"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1017\/CBO9780511623295.005","volume-title":"What is life? 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