{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:01:00Z","timestamp":1792501260882,"version":"4.5.0"},"reference-count":105,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T00:00:00Z","timestamp":1130371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2005,12,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mosquito behavior is heavily dependent on olfactory and mechanosensory cues, which are detected by receptor neurons on the antenna and on the palps. Recent progress in mosquito sensory genomics highlights the need for an up\u2010to\u2010date understanding of the neural architecture of the mosquito brain. Here we present a detailed description of the neural structure of the primary target of the majority of these neurons, the deutocerebrum, in the African malaria (<jats:italic>Anopheles gambiae<\/jats:italic>) and yellow fever (<jats:italic>Aedes aegypti<\/jats:italic>) mosquitoes. Special focus is made on the olfactory system, the antennal lobe (AL), where we present high\u2010resolution three\u2010dimensional models of the ALs of male and female <jats:italic>Ae. aegypti<\/jats:italic>. These models reveal a sexual dimorphism in the number of glomeruli, 49 and 50 glomeruli in male and female mosquitoes, respectively, and in the size of several of the identified glomeruli. The fine structure of receptor neuron terminations in the AL and the rest of the deutocerebrum is described, as are the arborizations of intrinsic deutocerebral neurons and neurons providing output to higher brain areas. In the AL a specific and very large center receiving input from the mechanosensory Johnston's organ is revealed as a multilobed structure receiving peripheral input according to a somatotopic pattern. Within the antennal nerve a specific neuropil containing early, bouton\u2010like ramifications of receptor neurons is described. Within the glomerular array of the AL, neurons providing a possible feedback circuit to antennal receptor neurons are shown. With these results we provide a new resolution in mosquito deutocerebral architecture. J. Comp. Neurol. 493:207\u2013240, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20800","type":"journal-article","created":{"date-parts":[[2005,10,28]],"date-time":"2005-10-28T00:47:56Z","timestamp":1130460476000},"page":"207-240","source":"Crossref","is-referenced-by-count":151,"title":["Neuronal architecture of the mosquito deutocerebrum"],"prefix":"10.1002","volume":"493","author":[{"given":"Rickard","family":"Ignell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teun","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Ghaninia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill S.","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1289"},{"key":"e_1_2_6_3_1","first-page":"184","volume-title":"Olfaction in mosquito\u2010host interaction","author":"Anton S","year":"1996"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-07911-9_5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20174"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asd.2003.09.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225425"},{"key":"e_1_2_6_8_1","first-page":"269","volume-title":"G\u00f6ttingen neurobiology report","author":"Bausenwein B","year":"1996"},{"key":"e_1_2_6_9_1","first-page":"386","volume-title":"New neuroethology on the move","author":"Bausenwein B","year":"1998"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/cne.10180","article-title":"Digital atlases of the antennal lobe in two species of tobacco budworm moths, the oriental Helicoverpa assulta (male) and the American Heliothis virescens (male and female)","volume":"46","author":"Berg B","year":"2002","journal-title":"J Comp Neurol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090650110"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00603661"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF00925461","article-title":"Fine structure of the antennal sensory hairs in female Anopheles stephensi","volume":"61","author":"Boo KS","year":"1980","journal-title":"Z Parasitenkunde"},{"key":"e_1_2_6_14_1","first-page":"264","article-title":"Antennal sensory receptors of the male mosquito, Anopheles stephensi","volume":"61","author":"Boo KS","year":"1980","journal-title":"Z Parasitenkunde"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.36.010191.001035"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/27.3.231"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7322(81)80019-0"},{"key":"e_1_2_6_18_1","volume-title":"The insects: structure and function","author":"Chapman RF","year":"1971"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/z84-190"},{"key":"e_1_2_6_20_1","series-title":"Neuroethology of sexual attraction and inhibition in heliothine moths. Neural basis of behavioural adaptations. Progress in zoology","first-page":"37","author":"Christensen TA","year":"1994"},{"key":"e_1_2_6_21_1","first-page":"201","volume-title":"The neurobiology of taste and smell","author":"Christensen TA","year":"2000"},{"key":"e_1_2_6_22_1","series-title":"The biology of mosquitoes","volume-title":"Sensory reception and behaviour","author":"Clements AN","year":"1999"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1830705100"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01736"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1242\/jeb.200.13.1873","article-title":"Central projections of the maxillary and antennal nerves in the mosquito Aedes aegypti","volume":"200","author":"Distler PG","year":"1997","journal-title":"J Exp Biol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00094-1"},{"key":"e_1_2_6_27_1","first-page":"556","article-title":"\u00dcber den einheitligen Bau des Gehirns in den verschiedenen Insektenornungen","volume":"30","author":"Fl\u00f6gel JHL","year":"1878","journal-title":"Z Wiss Zool"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"14693","DOI":"10.1073\/pnas.261432998","article-title":"Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down\u2010regulation in response to blood feeding","volume":"98","author":"Fox AN","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00109-4"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1910(00)00106-2"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051245"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001140050669"},{"key":"e_1_2_6_33_1","first-page":"473","article-title":"The glomerular code for odor representation is species specific in the honey bee Apis mellifera","volume":"2","author":"Galizia CG","year":"1999","journal-title":"Nature"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003590000156"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/77680"},{"key":"e_1_2_6_36_1","first-page":"184","volume-title":"Olfaction in mosquito interactions","author":"Grant AJ","year":"1996"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00187475"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20173"},{"key":"e_1_2_6_39_1","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1242\/jeb.205.9.1199","article-title":"The mechanical basis of Drosophila audition","volume":"205","author":"G\u00f6pfert M","year":"2002","journal-title":"J Exp Biol"},{"key":"e_1_2_6_40_1","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1242\/jeb.202.20.2727","article-title":"Mosquito hearing: sound\u2010induced antennal vibrations in male and female Aedes aegypti","volume":"202","author":"G\u00f6pfert MC","year":"1999","journal-title":"J Exp Biol"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-004-0529-0"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/366059a0"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-07911-9_6"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903120209"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1598574"},{"key":"e_1_2_6_46_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s003590050130","article-title":"Dose\u2010dependent response characteristics of antennal lobe neurons in the male moth Agrotis segetum (Lepidoptera: Noctuidae)","volume":"181","author":"Hartlieb E","year":"1997","journal-title":"J Comp Physiol A"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076181"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-07911-9_8"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225800"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.34.010189.002401"},{"key":"e_1_2_6_51_1","first-page":"319","volume-title":"Methods in insect sensory neuroscience","author":"Ignell R","year":"2005"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20691"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1467-8039(01)00016-0"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047222"},{"key":"e_1_2_6_55_1","first-page":"155","article-title":"Comparative study of sense organs in the antennae of culicine and anopheline female mosquitoes","volume":"21","author":"Ismail IAH","year":"1964","journal-title":"Acta Trop"},{"key":"e_1_2_6_56_1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1523\/JNEUROSCI.16-02-00769.1996","article-title":"Functional organization of a neural map in the cricket cercal sensory system","volume":"16","author":"Jacobs GA","year":"1996","journal-title":"J Neurosci"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/387285a0"},{"key":"e_1_2_6_58_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/BF00611233","article-title":"Physiology and morphology of projection neurons in the antennal lobe of the male moth, Manduca sexta","volume":"165","author":"Kanzaki R","year":"1989","journal-title":"J Comp Physiol A"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.910060302"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1086\/276614"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2003.2331"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990322)405:4<543::AID-CNE7>3.0.CO;2-A"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1108"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00700-6"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903090304"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1910(78)90079-3"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/19.5.489"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1910(79)90032-5"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:18:3:239"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022432909360"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:14:1-2:017"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00057-6"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00975-3"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7322(89)90033-0"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-8166(95)80024-7"},{"key":"e_1_2_6_76_1","unstructured":"OmerSM.1971.The role of sense organs on the antennae and palpi in the host\u2010seeking behaviour of mosquitoes. PhD Thesis University of Sussex UK."},{"key":"e_1_2_6_77_1","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1523\/JNEUROSCI.19-05-01771.1999","article-title":"Neural mapping of direction and frequency in the cricket cercal sensory system","volume":"19","author":"Paydar S","year":"1999","journal-title":"J Neurosci"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(02)00378-1"},{"key":"e_1_2_6_79_1","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1152\/jn.1996.75.4.1365","article-title":"Information theoretic analysis of dynamical encoding by filiform mechanoreceptors in the cricket cercal system","volume":"75","author":"Roddey JC","year":"1996","journal-title":"J Neurophysiol"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902200108"},{"key":"e_1_2_6_81_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/978-1-4899-2519-0_23","volume-title":"Neurobiology of sensory systems","author":"Rospars JP","year":"1989"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00328007"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/27.9.803"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02931.x"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00826.x"},{"key":"e_1_2_6_86_1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1242\/jeb.205.10.1363","article-title":"Glomerular representation of plant volatiles and sex pheromone components in the antennal lobe of the female Spodoptera littoralis","volume":"205","author":"Sadek MM","year":"2002","journal-title":"J Exp Biol"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00263-X"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7322(85)90044-3"},{"key":"e_1_2_6_89_1","first-page":"60.2","article-title":"Synaptic ultrastructure of Drosophila Johnston's organ axon terminals","author":"Sivan Loukianova E","year":"2002","journal-title":"Soc Neurosci Abstr Viewer Itinerary Planner"},{"key":"e_1_2_6_90_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00441-002-0659-z","article-title":"Three\u2010dimensional organization of the glomeruli in the antennal lobe of the parasitoid wasps Cotesia glomerata and C. rubecula","volume":"312","author":"Smid HM","year":"2003","journal-title":"Cell Tissue Res"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.07.011"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00213783"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327741"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-66179-2"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10368"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.44.1.131"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-07911-9_4"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3032.1995.tb00826.x"},{"key":"e_1_2_6_99_1","first-page":"1","article-title":"Etudes histologiques et organologiques sur les centres nerveux et les organes des sens des animaux articules. Deuxieme memoire. Le ganglion optique de la libellule (Aeschna maculatissima)","volume":"18","author":"Viallanes H","year":"1884","journal-title":"Ann Sci Nat Zool"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.2307\/1542524"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80582-6"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80582-6"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00004-7"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.4039\/Ent94613-6"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00707-9"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2004.03.017"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.20800","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.20800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T14:51:42Z","timestamp":1697208702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.20800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,27]]},"references-count":105,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,12,12]]}},"alternative-id":["10.1002\/cne.20800"],"URL":"https:\/\/doi.org\/10.1002\/cne.20800","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,27]]}}}