{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:58:09Z","timestamp":1774940289183,"version":"3.50.1"},"reference-count":77,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,30]],"date-time":"2005-11-30T00:00:00Z","timestamp":1133308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2006,1,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To test for possible retention of early segmental patterning throughout development, the cranial nerve efferent nuclei in adult ranid frogs were quantitatively mapped and compared with the segmental organization of these nuclei in larvae. Cranial nerve roots IV\u2013X were labeled in larvae with fluorescent dextran amines. Each cranial nerve efferent nucleus resided in a characteristic segmental position within the clearly visible larval hindbrain rhombomeres (r). Trochlear motoneurons were located in r0, trigeminal motoneurons in r2\u2013r3, facial branchiomotor and vestibuloacoustic efferent neurons in r4, abducens and facial parasympathetic neurons in r5, glossopharyngeal motoneurons in r6, and vagal efferent neurons in r7\u2013r8 and rostral spinal cord. In adult frogs, biocytin labeling of cranial nerve roots IV\u2013XII and spinal ventral root 2 in various combinations on both sides of the brain revealed precisely the same rostrocaudal sequence of efferent nuclei relative to each other as observed in larvae. This indicates that no longitudinal migratory rearrangement of hindbrain efferent neurons occurs. Although rhombomeres are not visible in adults, a segmental map of adult cranial nerve efferent nuclei can be inferred from the strict retention of the larval hindbrain pattern. Precise measurements of the borders of adjacent efferent nuclei within a coordinate system based on external landmarks were used to create a quantitative adult segmental map that mirrors the organization of the larval rhombomeric framework. Plotting morphologically and physiologically identified hindbrain neurons onto this map allows the physiological properties of adult hindbrain neurons to be linked with the underlying genetically specified segmental framework. J. Comp. Neurol. 494:228\u2013245, 2006. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20801","type":"journal-article","created":{"date-parts":[[2005,11,30]],"date-time":"2005-11-30T15:48:13Z","timestamp":1133365693000},"page":"228-245","source":"Crossref","is-referenced-by-count":58,"title":["Preservation of segmental hindbrain organization in adult frogs"],"prefix":"10.1002","volume":"494","author":[{"given":"Hans","family":"Straka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Gilland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00111-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960603)369:3<451::AID-CNE9>3.0.CO;2-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0532"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03075-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900280205"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(96)00120-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20001127)427:4<522::AID-CNE3>3.0.CO;2-Y"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1242\/dev.124.13.2633","article-title":"Development of branchiomotor neurons in zebrafish","volume":"124","author":"Chandrasekhar A","year":"1997","journal-title":"Development"},{"key":"e_1_2_6_11_1","first-page":"28","article-title":"Synaptic input to oculomotor motoneurons in the frog","volume":"18","author":"Cochran SL","year":"1992","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_6_12_1","volume-title":"Development of the vertebrate skull","author":"de Beer G","year":"1937"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90529-B"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/13172"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000006564"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90430-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.24.5297"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01029"},{"key":"e_1_2_6_19_1","volume-title":"A. Ecker's und R. Wiedersheim's Anatomie des Frosches. Bd. II","author":"Gaupp E","year":"1899"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/BBLv183n2p356"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000147530"},{"key":"e_1_2_6_22_1","first-page":"183","article-title":"A simplified table for staging of anuran embryos and larvae with notes on identification","volume":"16","author":"Gosner KL","year":"1960","journal-title":"Herpetologica"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.77.5.2765"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901890105"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002040308"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-01-00206.2000"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210000670"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"7664","DOI":"10.1523\/JNEUROSCI.20-20-07664.2000","article-title":"Facial visceral motor neurons display specific rhombomere origin and axon pathfinding behavior in the chick","volume":"20","author":"Jacob J","year":"2000","journal-title":"J Neurosci"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91072-3"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(85)90130-X"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/337424a0"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb00693.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970616)382:4<499::AID-CNE6>3.0.CO;2-Y"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90376-K"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901780109"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960722)371:2<258::AID-CNE6>3.0.CO;2-1"},{"key":"e_1_2_6_37_1","first-page":"67","article-title":"Motoneurons differ in size and peripheral target in the trigeminal and facial nuclear complex of the frog","volume":"35","author":"Matesz C","year":"1994","journal-title":"J Brain Res"},{"key":"e_1_2_6_38_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1076\/ejom.37.2.190.4736","article-title":"Organization of the motor centres for the innervation of different muscles of the tongue: a neuromorphological study in the frog","volume":"37","author":"Matesz C","year":"1999","journal-title":"Eur J Morphol"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903310209"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10238"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00815"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00986"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-18262-4"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902590308"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90639-1"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20010226)431:1<105::AID-CNE1058>3.0.CO;2-P"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.12.030"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315925"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970113)377:2<149::AID-CNE1>3.0.CO;2-3"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2784-7_16"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902610308"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90631-3"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902780203"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406382102"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113323"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1356"},{"key":"e_1_2_6_57_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1159\/000143831","article-title":"Development of tegmental and rhombencephalic structures in a frog (Rana temporaria L.)","volume":"83","author":"Senn DG","year":"1972","journal-title":"Acta Anat"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90179-U"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903080402"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000147533"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-08-02718.1989"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1993.tb00491.x"},{"key":"e_1_2_6_63_1","first-page":"564.19","article-title":"Anatomical and functional organization of the vestibular commissure in frogs","volume":"28","author":"Straka H","year":"2002","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.2307\/1542849"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02768-2"},{"key":"e_1_2_6_66_1","first-page":"310","article-title":"Rhombomeric pattern of hindbrain efferent neurons is retained in adult frogs","volume":"26","author":"Straka H","year":"2000","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1268"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00670-0"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00372.2003"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902170407"},{"key":"e_1_2_6_71_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00218392","article-title":"Afferent and efferent components of the facial nerve in a frog, Rana pipiens","volume":"244","author":"Stuesse SL","year":"1986","journal-title":"Cell Tissue Res"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902220304"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90579-9"},{"key":"e_1_2_6_74_1","first-page":"1","article-title":"The segmentation of the primitive neural tube in chick embryos (Gallus domesticus). A morphological, histochemical and autoradiographical investigation","volume":"41","author":"Vaage S","year":"1969","journal-title":"Ergeb Anat Entwicklungsgesch"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902780204"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00214812"},{"key":"e_1_2_6_77_1","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1242\/dev.122.7.2143","article-title":"Persistence of rhombomeric organisation in the postsegmental hindbrain","volume":"122","author":"Wingate RJ","year":"1996","journal-title":"Development"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000814)424:1<47::AID-CNE4>3.0.CO;2-5"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.20801","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.20801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T08:48:53Z","timestamp":1700038133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.20801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,30]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,1,10]]}},"alternative-id":["10.1002\/cne.20801"],"URL":"https:\/\/doi.org\/10.1002\/cne.20801","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,30]]}}}