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The ONL can be differentiated into sublaminae: the outer (ONLo), where axons broadly target regions of the OB in tight fascicles, and inner (ONLi), where axons perform final targeting in loosely organized fascicles. During perinatal development, cadherin\u20102 and its binding partner, \u03b3\u2010catenin, are preferentially expressed by OSN axons in the ONLo vs. the ONLi. Given the expression of these cytoskeleton\u2010associated molecules, we hypothesized that cytoskeletal elements of OSN axons may be differentially expressed across the ONL. We therefore examined cytoskeletal organization of OSN axons in the ONL, focusing on the day of birth (P0). We show that microfilaments, microtubules, and the intermediate filament (IF) vimentin are homogeneously expressed across the ONL at P0. In contrast, the IFs peripherin and \u03b1\u2010internexin are preferentially localized to the ONLo at P0, with \u03b1\u2010internexin expressed by a restricted subset of OSNs. We also show that OSN axons in the ONLo are significantly smaller than those in the ONLi. The data demonstrate that, as OSN axons begin to exit the ONLo and target a specific region of the OB, there is a down\u2010regulation of cytoskeletal elements and bound extracellular adhesion molecules. The increase in axon diameter may reflect additional mechanisms involved in glomerular targeting or the formation of the large terminal boutons of OSN axons within glomeruli. J. Comp. Neurol. 494:358\u2013367, 2006. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20814","type":"journal-article","created":{"date-parts":[[2005,11,30]],"date-time":"2005-11-30T17:21:03Z","timestamp":1133371263000},"page":"358-367","source":"Crossref","is-referenced-by-count":23,"title":["Cytoskeletal organization of the developing mouse olfactory nerve layer"],"prefix":"10.1002","volume":"494","author":[{"given":"Michael R.","family":"Akins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Greer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,30]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"AkinsMR GreerCA.2005.Catenins define axon paths in the developing mouse olfactory system. 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