{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:20:47Z","timestamp":1790889647957,"version":"4.1.0"},"reference-count":104,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T00:00:00Z","timestamp":1146787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This is the first part of a two\u2010part study to investigate the cellular distribution and temporal regulation of \u03b1\u2010amino\u20103\u2010hydroxy\u20105\u2010methyl\u20104\u2010isoxazole\u2010propionic acid receptor (AMPAR) subunits in the developing white matter and cortex in rat (part I) and human (part II). Western blot and immunocytochemistry were used to evaluate the differential expression of AMPAR subunits on glial and neuronal subtypes during the first 3 postnatal weeks in the Long Evans and Sprague Dawley rat strains. In Long Evans rats during the first postnatal week, GluR2\u2010lacking AMPARs were expressed predominantly on white matter cells, including radial glia, premyelinating oligodendrocytes, and subplate neurons, whereas, during the second postnatal week, these AMPARs were highly expressed on cortical neurons, coincident with decreased expression on white matter cells. Immunocytochemical analysis revealed that cell\u2010specific developmental changes in AMPAR expression occurred 2\u20133 days earlier by chronological age in Sprague Dawley rats compared with Long Evans rats, despite overall similar temporal sequencing. In both white and gray matter, the periods of high GluR2 deficiency correspond to those of regional susceptibility to hypoxic\/ischemic injury in each of the two rat strains, supporting prior studies suggesting a critical role for Ca<jats:sup>2+<\/jats:sup>\u2010permeable AMPARs in excitotoxic cellular injury and epileptogenesis. The developmental regulation of these receptor subunits strongly suggests that Ca<jats:sup>2+<\/jats:sup> influx through GluR2\u2010lacking AMPARs may play an important role in neuronal and glial development and injury in the immature brain. Moreover, as demonstrated in part II, there are striking similarities between rat and human in the regional and temporal maturational regulation of neuronal and glial AMPAR expression. J. Comp. Neurol. 497:42\u201360, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20972","type":"journal-article","created":{"date-parts":[[2006,5,6]],"date-time":"2006-05-06T00:56:50Z","timestamp":1146877010000},"page":"42-60","source":"Crossref","is-referenced-by-count":140,"title":["Developmental regulation of \u03b1\u2010amino\u20103\u2010hydroxy\u20105\u2010methyl\u20104\u2010isoxazole\u2010propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic\/ischemic injury. I. Rodent cerebral white matter and cortex"],"prefix":"10.1002","volume":"497","author":[{"given":"Delia M.","family":"Talos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunkyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca D.","family":"Folkerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela L.","family":"Follett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Volpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances E.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00191452"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(90)90131-X"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(91)90214-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00455.2002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1962.04210050022004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb05396.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35012083"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90120-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02180-1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00163-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903430406"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00032-3"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.01003.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1136624100"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-01-00034.2000"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041996"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-09235.2000"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0477-04.2004"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1991.66.6.2059"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-08-02601.1990"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"9412","DOI":"10.1523\/JNEUROSCI.19-21-09412.1999","article-title":"Unilateral GluR2(B) hippocampal knockdown: a novel partial seizure model in the developing rat","volume":"19","author":"Friedman LK","year":"1999","journal-title":"J Neurosci"},{"key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1523\/JNEUROSCI.12-12-04816.1992","article-title":"Visualization of O\u20102A progenitor cells in developing and adult rat optic nerve by quisqualate\u2010stimulated cobalt uptake","volume":"12","author":"Fulton BP","year":"1992","journal-title":"J Neurosci"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440110204"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-08-02659.1996"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.7.4073"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1242\/dev.106.1.119","article-title":"Oligodendrocyte progenitors isolated directly from developing telencephalon at a specific phenotypic stage:myelinogenic potential in a defined environment","volume":"106","author":"Gard AL","year":"1989","journal-title":"Development"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.117.3.1031"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90999-4"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90385-9"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000243526"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10862"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/381793a0"},{"key":"e_1_2_5_34_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000480613","article-title":"Hypoxic\u2010ischemic damage in the neonatal rat brain: excitatory amino acids","volume":"18","author":"Hagberg H","year":"1992","journal-title":"Dev Pharmacol Ther"},{"key":"e_1_2_5_35_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000244109","article-title":"Hypoxic\u2010ischemic damage in the neonatal rat brain: histopathology after post\u2010treament with NMDA and non\u2010NMDA receptor antagonists","volume":"66","author":"Hagberg H","year":"1994","journal-title":"Biol Neonate"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-16-07165.2002"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1993.tb02586.x"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90221-C"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.17.030194.000335"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00866.x"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290610"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90375-1"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1995.tb00954.x"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.1.73"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1150"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19981015)54:2<273::AID-JNR15>3.0.CO;2-5"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90444-8"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084152"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199802)22:2<161::AID-GLIA7>3.0.CO;2-A"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1122"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.69103.x"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20216"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-08-03005.2002"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13491"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046149"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300485"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00732.2003"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200201000-00007"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00756-X"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199401120-00034"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(03)00059-5"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199805000-00007"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389801300702"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03308.2003"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(97)00055-5"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00420-2"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10710"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.116.1.201"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/35055553"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-08-03161.2002"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1997.tb07447.x"},{"key":"e_1_2_5_72_1","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1523\/JNEUROSCI.09-05-01701.1989","article-title":"MK\u2010801 prevents hypobaric\/ischemic neuronal damage in infant rat brain","volume":"9","author":"Olney JW","year":"1989","journal-title":"J Neurosci"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229137"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410210"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90277-1"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.10.4157"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90717-L"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903180309"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-02-00667.1994"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970901)385:3<456::AID-CNE9>3.0.CO;2-2"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)04114-8"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440205"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10472"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010079"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-20-08154.2001"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0204-05.2005"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0439fje"},{"key":"e_1_2_5_88_1","first-page":"297","article-title":"The TIPS\/TINS Lecture: the molecular biology of the mammalian glutamate receptor channels","volume":"14","author":"Seeburg PH","year":"1993","journal-title":"Trends Neurosci"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb00708.x"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.6.2916"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1159\/000244327"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199903)26:1<1::AID-GLIA1>3.0.CO;2-Z"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199112000-00021"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01279614"},{"key":"e_1_2_5_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.6.602"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903020103"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20978"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(01)00259-0"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(97)00036-9"},{"key":"e_1_2_5_100_1","volume-title":"Neurology of the newborn","author":"Volpe JJ","year":"2001"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-24-09393.1997"},{"key":"e_1_2_5_102_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0021-9258(18)48523-7","article-title":"Immunochemical characterization of the non\u2010NMDA glutamate receptor using subunit\u2010specific antibodies","volume":"267","author":"Wenthold RJ","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_5_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10425"},{"key":"e_1_2_5_104_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.15.2901"},{"key":"e_1_2_5_105_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4071-03.2004"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.20972","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.20972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T05:17:44Z","timestamp":1700025464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.20972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,5]]},"references-count":104,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1002\/cne.20972"],"URL":"https:\/\/doi.org\/10.1002\/cne.20972","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,5]]}}}