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In part I, we reported that, in rat, developmental expression of Ca<jats:sup>2+<\/jats:sup>\u2010permeable (GluR2\u2010lacking) AMPARs correlated at the regional and cellular level with increased susceptibility to hypoxia\/ischemia (H\/I), suggesting an age\u2010specific role of these receptors in the pathogenesis of brain injury. Part II examines the regional and cellular progression of AMPAR subunits in human white matter and cortex from midgestation through early childhood. Similarly to the case in the rodent, there is a direct correlation between selective vulnerability to H\/I and expression of GluR2\u2010lacking AMPARs in human brain. For midgestational cases aged 20\u201324 postconceptional weeks (PCW) and for premature infants (25\u201337 PCW), we found that radial glia, premyelinating oligodendrocytes, and subplate neurons transiently expressed GluR2\u2010lacking AMPARs. Notably, prematurity represents a developmental window of selective vulnerability for white matter injury, such as periventricular leukomalacia (PVL). During term (38\u201342 PCW) and postterm neonatal (43\u201346 PCW) periods, age windows characterized by increased susceptibility to cortical injury and seizures, GluR2 expression was low in the neocortex, specifically on cortical pyramidal and nonpyramidal neurons. This study indicates that Ca<jats:sup>2+<\/jats:sup>\u2010permeable AMPAR blockade may represent an age\u2010specific therapeutic strategy for potential use in humans. Furthermore, these data help to validate specific rodent maturational stages as appropriate models for evaluation of H\/I pathophysiology. J. Comp. Neurol. 497:61\u201377, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.20978","type":"journal-article","created":{"date-parts":[[2006,5,6]],"date-time":"2006-05-06T00:56:56Z","timestamp":1146877016000},"page":"61-77","source":"Crossref","is-referenced-by-count":154,"title":["Developmental regulation of \u03b1\u2010amino\u20103\u2010hydroxy\u20105\u2010methyl\u20104\u2010isoxazole\u2010propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic\/ischemic injury. II. 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