{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:32:18Z","timestamp":1789878738653,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T00:00:00Z","timestamp":1148947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2006,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amyotrophic lateral sclerosis (ALS) is a fatal adult human disease caused by motor neuron degeneration. Stem cell therapy might be a treatment for ALS. The adult mammalian forebrain has neural stem cells (NSCs) and neural progenitor cells (NPCs) in the anterior subventricular zone (SVZa), rostral migratory stream (RMS), olfactory bulb (OB) core, and dentate gyrus (DG). These cells could be used to rescue or replace degenerating upper and lower motor neurons through endogenous recruitment or autologous\/allogenic transplantation. We evaluated the competency of forebrain NSCs and NPCs in transgenic (tg) mice harboring human mutant superoxide dismutase\u20101 (mSOD1), a model of ALS. Tg human wild\u2010type SOD1 (wtSOD1) mice and non\u2010tg mice were controls. Bromodeoxyuridine (BrdU) labeling of cells, a marker for cell proliferation and other events, was reduced in a niche\u2010specific pattern in presymptomatic and symptomatic mice, with the SVZa having greater reductions than the RMS, OB, and DG. Different NSC and NPC complements were evaluated by localizing nestin, neural cell adhesion molecule, distalless\u20102 transcription factor, vimentin, and glial fibrillary acidic protein. In symptomatic mice, NSC markers were reduced, whereas NPC markers were unchanged or elevated. Neurogenesis was preserved in symptomatic mSOD1 mice. NSC\/NPC competence assessment in vitro revealed that mSOD1 SVZa cells had the ability to proliferate and form neurospheres but had an impaired response to mitogen stimulation. We conclude that adult mSOD1 ALS mice have abnormalities in forebrain NSCs, but the essential features of NSC\/NPCs remained in presymptomatic and symptomatic mice. J. Comp. Neurol. 497:468\u2013488, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21012","type":"journal-article","created":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T21:55:05Z","timestamp":1149026105000},"page":"468-488","source":"Crossref","is-referenced-by-count":61,"title":["The adult neural stem and progenitor cell niche is altered in amyotrophic lateral sclerosis mouse brain"],"prefix":"10.1002","volume":"497","author":[{"given":"Zhiping","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.1059"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091450409"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901370404"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-03-00629.2002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm747"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-21-08505.2001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(95)00019-Q"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2004.03.021"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00409-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.2144\/02325dd01","article-title":"Amyotrophic lateral sclerosis: from disease mechanisms to therapies","volume":"32","author":"Bruijn LI","year":"2002","journal-title":"Biotechniques"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1395"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-04-01446.2000"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406795101"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1523\/JNEUROSCI.21-09-03092.2001","article-title":"The expression pattern of the cell cycle inhibitor p19INK4d by progenitor cells of the rat embryonic telencephalon and neonatal anterior subventricular zone","volume":"21","author":"Coskun V","year":"2001","journal-title":"J Neurosci"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/367455a0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050650"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-13-05046.1997"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)01133-9"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2003.10.004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1340"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199808)36:2<234::AID-NEU10>3.0.CO;2-E"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00437.2002"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8209258"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1086\/426001"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00123-6"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250471697"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90662-X"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10037"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7526"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1064"},{"key":"e_1_2_6_32_1","first-page":"134.7","article-title":"The olfactory bulb is a novel source of neural stem cells in adult CNS: identification, isolation, and culture","volume":"27","author":"Liu Z","year":"2001","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10664"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2004.21.1479"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8178174"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90281-U"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2000.0314"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2004.09.004"},{"key":"e_1_2_6_39_1","volume-title":"Transplantation of adult olfactory bulb neural stem cells delays disease onset and prolongs survival in a mouse ALS model. 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