{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:59:27Z","timestamp":1791176367159,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T00:00:00Z","timestamp":1149033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The patterns of development of the vestibular nuclei (VN) and their main connections involving glutamate neurotransmission offer a good model for studying the function of the glial\u2010derived neuromodulator\n                    <jats:sc>D<\/jats:sc>\n                    \u2010serine in synaptic plasticity. In this study we show that\n                    <jats:sc>D<\/jats:sc>\n                    \u2010serine is present in the VN and we analyzed its distribution and the levels of expression of serine racemase and\n                    <jats:sc>D<\/jats:sc>\n                    \u2010amino acid oxidase (\n                    <jats:sc>D<\/jats:sc>\n                    \u2010AAO) at different stages of postnatal (P) development. From birth to P21, high levels of\n                    <jats:sc>D<\/jats:sc>\n                    \u2010serine were detected in glial cells and processes in all parts of the VN. This period corresponded to high expression of serine racemase and low expression of\n                    <jats:sc>D<\/jats:sc>\n                    \u2010AAO. On the other hand, in the mature VN\n                    <jats:sc>D<\/jats:sc>\n                    \u2010serine displayed very low levels and was mainly localized in neuronal cell bodies and dendrites. This drop of\n                    <jats:sc>D<\/jats:sc>\n                    \u2010serine in adult stages corresponded to an increasing expression of\n                    <jats:sc>D<\/jats:sc>\n                    \u2010AAO at mature stages. High levels of glial\n                    <jats:sc>D<\/jats:sc>\n                    \u2010serine during the first 3 weeks of postnatal development correspond to an intense period of plasticity and synaptogenesis and maturation of VN afferents, suggesting that\n                    <jats:sc>D<\/jats:sc>\n                    \u2010serine could be involved in these phenomena. These results demonstrate for the first time that changes in\n                    <jats:sc>D<\/jats:sc>\n                    \u2010serine levels and distribution occur during postnatal development in the central nervous system. The strong decrease of\n                    <jats:sc>D<\/jats:sc>\n                    \u2010serine levels and the glial\u2010to\u2010neuronal switch suggests that\n                    <jats:sc>D<\/jats:sc>\n                    \u2010serine may have distinct functional roles depending on the developmental stage of the vestibular network. J. Comp. Neurol. 497:610\u2013621, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/cne.21016","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T19:48:55Z","timestamp":1149104935000},"page":"610-621","source":"Crossref","is-referenced-by-count":48,"title":["Changes in\n                    <scp>D<\/scp>\n                    \u2010serine levels and localization during postnatal development of the rat vestibular nuclei"],"prefix":"10.1002","volume":"497","author":[{"given":"Julien","family":"Puyal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Martineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Mothet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Th\u00e9r\u00e8se","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.08.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01716-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199707280-00007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233493"},{"key":"e_1_2_7_6_1","first-page":"295","article-title":"Postnatal 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