{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:13:33Z","timestamp":1791281613689,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,17]],"date-time":"2006-08-17T00:00:00Z","timestamp":1155772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2006,10,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the central nervous system, steroidogenic factor 1 (SF\u20101) is required for terminal differentiation of neurons within the ventromedial hypothalamus (VMH). Given the importance of this brain region in regulating physiological homeostasis including energy balance, we asked how <jats:italic>sf\u20101<\/jats:italic> gene dosage affects VMH function. Despite an apparent normal VMH cytoarchitecture, <jats:italic>sf\u20101<\/jats:italic> heterozygous (+\/\u2212) mice exhibited diet\u2010induced obesity when they were group housed with hyperphagia and impaired sympathetic activity. On the basis of previous findings suggesting brain\u2010derived neurotrophic factor (<jats:italic>bdnf<\/jats:italic>) as an SF\u20101 target gene, we assessed the colocalization of SF\u20101 and BDNF expressing neurons, as well as expression of the four exon\u2010specific <jats:italic>bdnf<\/jats:italic> promoter transcripts in the VMH. Indeed, a subset of neurons located primarily in the ventrolateral VMH coexpress SF\u20101 and BDNF, and in contrast to other brain regions, <jats:italic>bdnf<\/jats:italic> I, II, and IV but not III are found. Consistent with these findings, cellular assays showed that SF\u20101 is able to activate exon I and IV promoters. More important, levels of <jats:italic>bdnf<\/jats:italic> I and IV in the VMH were reduced in heterozygous mice similar to levels observed in fasted wild\u2010type mice. Collectively, we propose that a reduction in the <jats:italic>sf\u20101<\/jats:italic> gene dosage directly affects BDNF levels in the VMH and disrupts normal hypothalamic function. J. Comp. Neurol. 498:637\u2013648, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21070","type":"journal-article","created":{"date-parts":[[2006,8,17]],"date-time":"2006-08-17T17:46:45Z","timestamp":1155836805000},"page":"637-648","source":"Crossref","is-referenced-by-count":75,"title":["Diminished hypothalamic <i>bdnf<\/i> expression and impaired VMH function are associated with reduced SF\u20101 gene dosage"],"prefix":"10.1002","volume":"498","author":[{"given":"Phu V.","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan F.","family":"Akana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Malkovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary 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