{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:08:47Z","timestamp":1789988927291,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T00:00:00Z","timestamp":1160092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serotonin (5\u2010HT) affects brain development during sensitive developmental periods. In rodents, transient sites of high affinity capture of 5\u2010HT were demonstrated in the primary sensory neurons and in the sensory thalamocortical afferents. This uptake is required to adjust 5\u2010HT receptor stimulation during the formation of sensory maps. To determine whether similar mechanisms exist in primates, we analyzed staged embryos and postnatal pups in the common marmoset (total gestation time, 142 days). Immunocytochemical analyses were performed using antisera to 5\u2010HT, to the serotonin transporter (SERT), and to the vesicular monoamine transporter (VMAT2). 5\u2010HT, SERT, and VMAT2 labeled the raphe neurons and their terminal network from embryonic day (E)70 to adulthood. In addition, from E70\u2013130 VMAT2 and SERT were observed in all the sensory cranial nerves, the olfactory nerve, the gustatory, the trigeminal, the auditory fibers, in the retinal ganglion cells, and the optic tract up to the lateral geniculate nucleus and the superior colliculus. All the spinal sensory ganglia and their peripheral sensory branches were labeled. Accumulation of 5\u2010HT was observed in all the sensory neurons expressing SERT and the corresponding axon tracts. Since these neurons were missing tryptophan hydroxylase (TPH), the synthesizing enzyme for 5\u2010HT, they most likely accumulated 5\u2010HT through the action of the amine transporters, as has been shown in rodents. No transient expression of 5\u2010HT markers was detectable in the sensory thalamocortical axons at any of the ages examined. Thus, the existence of 5\u2010HT uptake in nonserotoninergic neurons appears to be a conserved feature in primates, although the topographic extent of this transient expression is more restricted than that previously demonstrated in rodents. J. Comp. Neurol. 499:677\u2013689, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21137","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T20:35:45Z","timestamp":1160166945000},"page":"677-689","source":"Crossref","is-referenced-by-count":34,"title":["Transitory uptake of serotonin in the developing sensory pathways of the common marmoset"],"prefix":"10.1002","volume":"499","author":[{"given":"C.","family":"Lebrand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Hornung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,6]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Atlas of prenatal rat brain development","author":"Altman J","year":"1995"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00484-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1101678"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890070407"},{"key":"e_1_2_6_6_1","first-page":"321","volume-title":"Psychopharmacology: the fourth generation of progress","author":"Barker EL","year":"1995"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"7594","DOI":"10.1523\/JNEUROSCI.14-12-07594.1994","article-title":"Effect of serotonin depletion on vibrissa\u2010related patterns of thalamic afferents in the rat's somatosensory cortex","volume":"14","author":"Bennett\u2010Clarke CA","year":"1994","journal-title":"J Neurosci"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/354066a0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.196.1.263"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050868"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8211186"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0896-6273(00)80048-3","article-title":"Lack of barrels in the somatosensory cortex of monoamine oxidase A deficient mice: role of excess serotonin during the critical period","volume":"16","author":"Cases O","year":"1996","journal-title":"Neuron"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1523\/JNEUROSCI.18-17-06914.1998","article-title":"Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock\u2010outs","volume":"18","author":"Cases O","year":"1998","journal-title":"J Neurosci"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-31-09961.2003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.22.10993"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-10-03946.1992"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1256"},{"key":"e_1_2_6_18_1","first-page":"9","article-title":"Identification of serotonergic neurons in human brain by a monoclonal antibody binding to all three aromatic amino acid hydroxylases","volume":"426","author":"Haan EA","year":"1987","journal-title":"Brain Res"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00444-2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(89)90082-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1948036"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960408)367:3<413::AID-CNE7>3.0.CO;2-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1984.0021"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228794"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1523\/JNEUROSCI.04-01-00025.1984","article-title":"Development of prestriate visual projections in the monkey and human fetal cerebrum revealed by transient cholinesterase staining","volume":"4","author":"Kostovic I","year":"1984","journal-title":"J Neurosci"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80432-T"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1177\/29.3.7016977","article-title":"A novel immunocytochemical model system for specificity and sensitivity screening of antisera against multiple antigens","volume":"29","author":"Larsen L","year":"1981","journal-title":"J Histochem Cytochem"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1242\/dev.102.4.709","article-title":"Serotonin and morphogenesis. I. Sites of serotonin uptake and binding protein immunoreactivity in the midgestation mouse embryo","volume":"102","author":"Lauder JM","year":"1988","journal-title":"Development"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1523\/JNEUROSCI.22-03-00886.2002","article-title":"Activity\u2010dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice","volume":"22","author":"Laurent A","year":"2002","journal-title":"J Neurosci"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80215-9"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981130)401:4<506::AID-CNE5>3.0.CO;2-#"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902740211"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.20.1.125"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90425-C"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-02-00771.2000"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0069"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228550"},{"key":"e_1_2_6_38_1","series-title":"Handbook of chemical neuroanatomy","first-page":"141","volume-title":"Classical transmitters and receptors in the CNS","author":"Ottersen OP","year":"1984"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5400.401"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-09-06179.1995"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-02-01261.1995"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1977.0040"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-19-08541.2002"},{"key":"e_1_2_6_44_1","unstructured":"RichterSJ.1983.Die embryonale und ferale Morphogenese des Hirns und seiner Derivate beim Marmoset (Callithrix jacchus). MD thesis Free University of Berlin Germany."},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(93)90109-S"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-03-00884.2001"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420460407"},{"key":"e_1_2_6_48_1","volume-title":"The brain of the common marmoset","author":"Stephan H","year":"1980"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-16-07007.1999"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00602-9"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10089"},{"key":"e_1_2_6_52_1","first-page":"1","article-title":"Effects of monoamine oxidase A inhibition on barrel formation in the mouse somatosensory cortex: determination of a sensitive developmental period","volume":"392","author":"Vitalis T","year":"1998","journal-title":"J Comp Neurol"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02736730"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(96)00209-4"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.21137","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.21137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:20:56Z","timestamp":1696983656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.21137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,6]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1002\/cne.21137"],"URL":"https:\/\/doi.org\/10.1002\/cne.21137","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,6]]}}}