{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:41:01Z","timestamp":1791268861476,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T00:00:00Z","timestamp":1161907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2006,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The projection of olfactory sensory neuron (OSN) axons to the olfactory bulb (OB) is a complex but well\u2010regulated process. Although odorant receptor proteins, and other molecules, are implicated in this process, our understanding remains incomplete. We demonstrate that axons remain restricted to the outer olfactory nerve layer (ONLo) until they are proximal to their target glomeruli, where they enter the inner ONL (ONLi), dividing the ONL into extension and sorting zones. Sorting is likely contingent on cell:cell interactions mediated in part by cell adhesion molecules. The cadherins are a large family of adhesion molecules whose function is contingent on their intracellular binding partners, the catenins, which in turn link to the cytoskeleton. We previously demonstrated that the organization of the cytoskeleton changed as olfactory sensory neuron axons moved from the ONLo to the ONLi. To further assess the role of cadherin mediated adhesion in the developing mouse ONL, we localized \u03b1\u2010, \u03b2\u2010, \u03b3\u2010, \u03b4\u2010, and p120\u2010catenins as well as neural cadherin (N\u2010cadherin; CDH2) in the OB. \u03b1\u2010 and \u03b2\u2010catenins are found throughout the OB and are uniform throughout the ONL. In contrast, \u03b3\u2010catenin and CDH2 are expressed predominantly in the ONLo during perinatal development, but are uniform across the ONL beginning at P7 and into adulthood. Finally, p120\u2010 and \u03b4\u2010catenins are expressed in nonoverlapping patterns by olfactory axons and OB neuronal dendrites, respectively. We conclude that \u03b3\u2010catenin\u2010mediated CDH2 adhesion may influence OSN targeting by restricting axons to the ONLo until they reach the appropriate domain of the OB. J. Comp. Neurol. 499:979\u2013989, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21147","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T14:47:09Z","timestamp":1161960429000},"page":"979-989","source":"Crossref","is-referenced-by-count":25,"title":["Axon behavior in the olfactory nerve reflects the involvement of catenin\u2013cadherin mediated adhesion"],"prefix":"10.1002","volume":"499","author":[{"given":"Michael R.","family":"Akins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Greer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20814"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00944-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10182"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0092-8674(02)00813-9","article-title":"Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target","volume":"110","author":"Brittis PA","year":"2002","journal-title":"Cell"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)01205-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00030-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200305137"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200307111"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005384200"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90194-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.05.011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.05.013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960226)366:1<1::AID-CNE1>3.0.CO;2-7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1242\/jcs.114.4.695","article-title":"p120 catenin affects cell motility via modulation of activity of Rho\u2010family GTPases: a link between cell\u2010cell contact formation and regulation of cell locomotion","volume":"114","author":"Grosheva I","year":"2001","journal-title":"J Cell Sci"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.125.6.1327"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901690103"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-03-00995.1999"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10323"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0364"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110052200"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990503)407:2<261::AID-CNE7>3.0.CO;2-G"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2002.5503"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980112)390:2<256::AID-CNE8>3.0.CO;2-0"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200818200"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10910"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20293"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200211025"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(89)90179-6"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81387-2"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.125.6.1341"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094291"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-03-00757.2002"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3777"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.3.567"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1993.1314"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(200005)43:2<173::AID-NEU7>3.0.CO;2-#"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200310090"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.15.3978"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-24-09713.2001"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90015-9"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0183"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-22-09856.1999"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1072"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990927)412:3<439::AID-CNE5>3.0.CO;2-H"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195159561.003.0005"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023374407724"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjg068"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10777"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90125-W"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80497-3"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02469.2002"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10590"},{"key":"e_1_2_6_54_1","first-page":"93","article-title":"Cytoplasmic domain of protocadherin\u2010alpha enhances homophilic interactions and recognizes cytoskeletal elements","volume":"66","author":"Triana\u2010Baltzer GB","year":"2006","journal-title":"J Neurobiol"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00207-0"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.135.3.767"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90029-9"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81145-9"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960916)373:2<240::AID-CNE7>3.0.CO;2-3"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200306001"},{"key":"e_1_2_6_61_1","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1523\/JNEUROSCI.15-06-04556.1995","article-title":"Lamina\u2010specific expression of adhesion molecules in developing chick optic tectum","volume":"15","author":"Yamagata M","year":"1995","journal-title":"J Neurosci"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-15-05830.1997"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.18.3127"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093468"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.21147","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.21147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T10:29:42Z","timestamp":1697192982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.21147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,27]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12,20]]}},"alternative-id":["10.1002\/cne.21147"],"URL":"https:\/\/doi.org\/10.1002\/cne.21147","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,27]]}}}