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We report here the developmental basis of these hippocampal abnormalities. A heterotopic band of neurons was identified starting at E17.5 in the CA3 region and progressing throughout the CA1 region by E18.5. At neonatal stages, the CA1 heterotopic band was reduced, but the CA3 band remained unchanged, continuing into adulthood. Thus, in mouse, migration of CA3 neurons is arrested during development, whereas CA1 cell migration is retarded. On the Sv129<jats:italic>Pas<\/jats:italic> background, magnetic resonance imaging (MRI) also suggested abnormal dorsal hippocampal morphology, displaced laterally and sometimes rostrally and associated with medial brain structure abnormalities. MRI and cryosectioning showed agenesis of the corpus callosum in <jats:italic>Dcx<\/jats:italic> knockout mice on this background and an intermediate, partial agenesis in heterozygote mice. Wild\u2010type littermates showed no callosal abnormalities. Hippocampal and corpus callosal abnormalities were also characterized in <jats:italic>DCX<\/jats:italic>\u2010mutated human patients. Severe hippocampal hypoplasia was identified along with variable corpus callosal defects ranging from total agenesis to an abnormally thick or thin callosum. Our data in the mouse, identifying roles for Dcx in hippocampal and corpus callosal development, might suggest intrinsic roles for human DCX in the development of these structures. J. Comp. Neurol. 500:239\u2013254, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21170","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T21:34:54Z","timestamp":1163799294000},"page":"239-254","source":"Crossref","is-referenced-by-count":68,"title":["Magnetic resonance imaging and histological studies of corpus callosal and hippocampal abnormalities linked to <i>doublecortin<\/i> deficiency"],"prefix":"10.1002","volume":"500","author":[{"given":"Caroline","family":"Kappeler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Dhenain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Phan Dinh 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