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We here investigate two lamprey species, the sea lamprey,<jats:italic>Petromyzon marinus<\/jats:italic>, and the river lamprey,<jats:italic>Lampetra fluviatilis<\/jats:italic>, and compare the GABA pattern with that of other vertebrates. The present immunohistochemical study provides an anatomical basis for the general distribution and precise localization of GABAergic neurons in the adult lamprey forebrain and brainstem. GABA\u2010immunoreactive cells were organized in a virtually identical manner in the two species. They were found throughout the brain, with the following regions being of particular interest: the granular cell layer of the olfactory bulb, the nucleus of the anterior commissure, the septum, the lateral and medial pallia, the striatum, the nucleus of the postoptic commissure, the thalamus, the hypothalamus, and pretectal areas, the optic tectum, the torus semicircularis, the mesencephalic tegmentum, restricted regions of the rhombencephalic tegmentum, the octavolateral area, and the dorsal column nucleus. The GABA distribution found in cyclostomes is very similar to that of other classes of vertebrates, including mammals. Since the lamprey diverged from the main vertebrate line around 450 million years ago, this implies that already at that time the basic vertebrate plan for the GABA innervation in different parts of the brain had been developed. J. Comp. Neurol. 503:47\u201363, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21348","type":"journal-article","created":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T19:27:12Z","timestamp":1178306832000},"page":"47-63","source":"Crossref","is-referenced-by-count":71,"title":["GABA distribution in lamprey is phylogenetically 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