{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:33:56Z","timestamp":1772573636840,"version":"3.50.1"},"reference-count":158,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,10,19]],"date-time":"2007-10-19T00:00:00Z","timestamp":1192752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2007,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The R6\/2 mouse possesses mutant exon 1 of human <jats:italic>Hdh<\/jats:italic>, and R6\/2 mice with 150 CAG repeats show neurological abnormalities by 10 weeks and die by 15 weeks. Few brain abnormalities, however, are evident at death, other than widespread ubiquitinated neuronal intranuclear inclusions (NIIs). We constructed R6\/2<jats:italic>t<\/jats:italic>+\/<jats:italic>t<\/jats:italic>\u2212 \u2194 wildtype (WT) chimeric mice to prolong survival of R6\/2 cells and determine if neuronal death and\/or neuronal injury become evident with longer survival. ROSA26 mice (which bear a <jats:italic>lacZ<\/jats:italic> transgene) were used as WT to distinguish between R6\/2 and WT neurons. Chimeric mice consisting partly of R6\/2 cells lived longer than pure R6\/2 mice (up to 10 months), with the survival proportional to the R6\/2 contribution. Genotypically R6\/2 cells formed NIIs in the chimeras, and these NIIs grew only slightly larger than in 12\u2010week pure R6\/2 mice, even after 10 months. Additionally, neuropil aggregates formed near R6\/2 neurons in chimeric mice older than 15 weeks. Thus, R6\/2 neurons could survive well beyond 15 weeks in chimeras. Moreover, little neuronal degeneration was evident in either cortex or striatum by routine histological stains. Nonetheless, striatal shrinkage and ventricular enlargement occurred, and striatal projection neuron markers characteristically reduced in Huntington's disease were diminished. Consistent with such abnormalities, cortex and striatum in chimeras showed increased astrocytic glial fibrillary acidic protein. These results suggest that while cortical and striatal neurons can survive nearly a year with nuclear and extranuclear aggregates of mutant huntingtin, such lengthy survival does reveal cortical and striatal abnormality brought on by the truncated mutant protein. J. Comp. Neurol. 505:603\u2013629, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21515","type":"journal-article","created":{"date-parts":[[2007,10,19]],"date-time":"2007-10-19T17:13:34Z","timestamp":1192814014000},"page":"603-629","source":"Crossref","is-referenced-by-count":34,"title":["R6\/2 neurons with intranuclear inclusions survive for prolonged periods in the brains of chimeric mice"],"prefix":"10.1002","volume":"505","author":[{"given":"Anton","family":"Reiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobel","family":"Del Mar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Ping","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Meade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Goldowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)93943-R"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270403"},{"key":"e_1_2_6_4_1","first-page":"1923","article-title":"Abnormalities of striatal projection neurons and N\u2010methyl\u2010D\u2010aspartate receptors in presymptomatic Huntington's disease","volume":"332","author":"Albin RL","year":"1990","journal-title":"N Engl J Med"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310412"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02257483"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902950302"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0451"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02998"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3920-03.2004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi340"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120166397"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi064"},{"key":"e_1_2_6_14_1","first-page":"267","volume-title":"Handbook of clinical neurology","author":"Bruyn GW","year":"1986"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1806"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90091-H"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(88)90027-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(90)90014-L"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1244"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00961.2003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6480"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1098\/rstb.1999.0449","article-title":"Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease","volume":"354","author":"Cha JHJ","year":"1999","journal-title":"Philos Trans R Soc Lond"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0306-4522(97)00452-1","article-title":"Evidence for the preferential localization of GluR1 subunits of AMPA receptors to the dendritic spines of medium spiny neurons in rat striatum","volume":"83","author":"Chen Q","year":"1997","journal-title":"Neuroscience"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182276099"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.5.783"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1503"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.7.3532"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81035-1"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80513-9"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1984.tb01355.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/00005072-198809000-00003","article-title":"Morphometric demonstrations of atrophic changes in the cerebral cortex, white matter, and neostriatum in Huntington's disease","volume":"44","author":"De La Monte SM","year":"1988","journal-title":"J Neuropathol Exp Neurol"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2004.02.005"},{"key":"e_1_2_6_34_1","first-page":"167","article-title":"Differential localization of the GluR1 and GluR2 subunits of the AMPA\u2010type glutamate receptor among striatal neuron types in rats","volume":"33","author":"Deng YP","year":"2007","journal-title":"J Chem"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90346-1"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5334.1990"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7618107"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90380-X"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(76)90063-4"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1994.tb00838.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.9.1463"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2931802"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90634-8"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198701000-00002"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90694-9"},{"key":"e_1_2_6_46_1","first-page":"169","article-title":"Parvalbumin\u2010immunoreactive neurons in the cerebral cortex and striatum in Huntington's disease","volume":"3","author":"Ferrer I","year":"1994","journal-title":"Neurodegeneration"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1145"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6724"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.5.9.1513"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-04-01189.1999"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.018"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91217-6"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00008-7"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-442"},{"key":"e_1_2_6_55_1","first-page":"271","volume-title":"Techniques for the genetic analysis of brain and behavior","author":"Goldowitz D","year":"1992"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3155875"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7626"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.47.1.201"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-07-02522.1999"},{"key":"e_1_2_6_60_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1399-0004.1998.tb02687.x","article-title":"The fatal attraction of polyglutamine\u2010containing proteins","volume":"53","author":"Hackham AS","year":"1998","journal-title":"Clin Gen"},{"key":"e_1_2_6_61_1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1083\/jcb.141.5.1097","article-title":"The influence of huntingtin protein size on nuclear localization and cellular toxicity","volume":"141","author":"Hackham AS","year":"1998","journal-title":"J Cell Biol"},{"key":"e_1_2_6_62_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/hmg\/8.1.25","article-title":"In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease","volume":"8","author":"Hackham AS","year":"1999","journal-title":"Hum Mol Gen"},{"key":"e_1_2_6_63_1","first-page":"309","article-title":"Parvalbumin immunoreactive neurons resist degeneration in Huntington's disease striatum","volume":"50","author":"Harrington KM","year":"1991","journal-title":"J Neuropathol Exp Neurol"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90583-F"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(03)00185-0"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80764-3"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.09.034"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0750830.x"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80573-5"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(99)00142-9"},{"key":"e_1_2_6_72_1","doi-asserted-by":"crossref","first-page":"7314","DOI":"10.1016\/S0021-9258(18)48238-5","article-title":"Ca2+\u2010binding parvalbumin in rat testis. Characterization, localization, and expression during development","volume":"262","author":"Kagi U","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)98374-8"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80581-4"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-03-00964.1999"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90866-A"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.6.2667"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81781-X"},{"key":"e_1_2_6_79_1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1073\/pnas.84.3.881","article-title":"Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A","volume":"84","author":"Krause JE","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.3374"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199912)46:6<842::AID-ANA6>3.0.CO;2-O"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-23-09112.2001"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.5.777"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/78054"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2003.08.006"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.79.3.637"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.2.137"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.9.1259"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.17.1911"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199902000-00003"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81369-0"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298-150"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7530"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10295"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7327"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-18-08266.2002"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010887421592"},{"key":"e_1_2_6_98_1","first-page":"615","article-title":"Homozygote for Huntington's disease","volume":"45","author":"Myers RH","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90542-1"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134108"},{"key":"e_1_2_6_101_1","first-page":"54","article-title":"Transgenic expression to monitor dynamic organization of neuronal development: use of the E. coli lacZ gene product, \u03b2\u2010galactosidase","volume":"5","author":"Oberdick J","year":"1994","journal-title":"Neuroprotocols"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80464-X"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470846410.ch8"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.9.3033"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.1996.0018"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5327.837"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb04879.x"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1409-03.2004"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/2510"},{"key":"e_1_2_6_110_1","first-page":"1035","article-title":"Transgenic mice expressing mutated full\u2010length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease","volume":"354","author":"Reddy PH","year":"1999","journal-title":"Proc R Soc Lond"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902590106"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1159\/000114379"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(90)90003-7"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.15.5733"},{"key":"e_1_2_6_115_1","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.1523\/JNEUROSCI.21-19-07608.2001","article-title":"Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice","volume":"21","author":"Reiner A","year":"2001","journal-title":"J Neurosci"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1385\/MN:28:3:259"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.721773.x"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370309"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-10-03705.2000"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.5.695"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000065888.88988.6E"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000174432.87383.87"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80716-3"},{"key":"e_1_2_6_124_1","first-page":"373","article-title":"Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders","volume":"421","author":"Sanchez I","year":"2003","journal-title":"Science"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00427-7"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420411"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199902000-00006"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81782-1"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80514-0"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.8.1365"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.3.397"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh175"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90345-3"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.7005"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.17.1953"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81743-2"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg169"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503634102"},{"key":"e_1_2_6_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03374.x"},{"key":"e_1_2_6_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20680"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320408"},{"key":"e_1_2_6_142_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2002.0554"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200001)47:1<80::AID-ANA13>3.0.CO;2-K"},{"key":"e_1_2_6_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.10.037"},{"key":"e_1_2_6_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-104"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2034961100"},{"key":"e_1_2_6_147_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.18.8195-8209.2004"},{"key":"e_1_2_6_148_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.110078997"},{"key":"e_1_2_6_149_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6832"},{"key":"e_1_2_6_150_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198511000-00003"},{"key":"e_1_2_6_151_1","doi-asserted-by":"crossref","first-page":"9159","DOI":"10.1074\/jbc.273.15.9158","article-title":"Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polygluamine tract","volume":"273","author":"Wellington CL","year":"1998","journal-title":"J Biol Chem"},{"key":"e_1_2_6_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/326194a0"},{"key":"e_1_2_6_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297-404"},{"key":"e_1_2_6_154_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688638708405354"},{"key":"e_1_2_6_155_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.4.481"},{"key":"e_1_2_6_156_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.23.2905"},{"key":"e_1_2_6_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00527-9"},{"key":"e_1_2_6_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-155"},{"key":"e_1_2_6_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2006.00573.x"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.21515","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.21515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T18:51:47Z","timestamp":1697223107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.21515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,19]]},"references-count":158,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12,20]]}},"alternative-id":["10.1002\/cne.21515"],"URL":"https:\/\/doi.org\/10.1002\/cne.21515","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,19]]}}}