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What expression patterns have in common is that 1) they are global, in the sense that all lineages of the central brain or optic lobe, or both, show expression; and 2) expression is stage\u2010specific: some cadherins are expressed only in primary neurons (located closest to the neuropile), others in early secondary neurons (near the brain surface), or primaries plus late secondaries. The Fat\u2010like cadherins, Fat and Dachsous, as well as Cad96Ca and Cad74A, are expressed in the epithelial optic lobe anlagen, which matches the widespread epithelial expression of these molecules in the embryo. DE\u2010cadherin is restricted to immature secondary neurons and glia; by contrast, DN\u2010cadherin, Flamingo, Cad87A, Cad99C, and Calsyntenin\u20101 appear in differentiating primary neurons and, at a later stage, some or all secondary neurons. Cad87A is strongly enriched apically in epithelia and in neuronal dendrites. Fat\u2010like, Cad86C, Cad88C, Cad89D, and Dret are expressed ubiquitously in embryonic and larval brains at low or moderate levels. We conclude from this analysis that cadherins are likely to play a role in \u2018generic\u2019 neural functions, such as neurite fasciculation, branching, and synapse formation. J. Comp. Neurol. 506:469\u2013488, 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21539","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T22:46:25Z","timestamp":1196203585000},"page":"469-488","source":"Crossref","is-referenced-by-count":35,"title":["Expression profile of the cadherin family in the developing <i>Drosophila<\/i> brain"],"prefix":"10.1002","volume":"506","author":[{"given":"Siaumin","family":"Fung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fay","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maretta","family":"Chase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Godt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Hartenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19960616)61:4<514::AID-JCB4>3.0.CO;2-R"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/321277"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg358"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2003.00109.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00152-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/83837"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.16.1709"},{"key":"e_1_2_6_9_1","volume-title":"Drosophila, a laboratory manual","author":"Ashburner M","year":"1989"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313878200"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.23.5421"},{"key":"e_1_2_6_12_1","unstructured":"ChaseM.2003.A molecular and genetic analysis of Drosophila cadherin Cad87A. 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