{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T19:10:11Z","timestamp":1699989011761},"reference-count":87,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Presynaptic ionotropic glutamate receptors modulate transmission at primary afferent synapses in several glutamatergic systems. To test whether primary gustatory afferent fibers express Ca<jats:sup>2+<\/jats:sup>\u2010permeable AMPA\/kainate receptors, we utilized kainate\u2010stimulated uptake of Co<jats:sup>2+<\/jats:sup> along with immunocytochemistry for the Ca<jats:sup>2+<\/jats:sup>\u2010binding proteins (CaBPs) calbindin and calretinin to investigate the primary gustatory afferents in goldfish (<jats:italic>Carassius auratus<\/jats:italic>). In goldfish, the primary gustatory nucleus (equivalent to the gustatory portion of the nucleus of the solitary tract) includes the vagal lobe, which is a large, laminated structure protruding dorsally from the medulla. Kainate\u2010stimulated uptake of Co<jats:sup>2+<\/jats:sup> (a measure of Ca<jats:sup>2+<\/jats:sup>\u2010fluxing glutamate receptors) shows punctate staining distributed in the distinct laminar pattern matching the layers of termination of the primary gustatory afferent fibers. In addition, CaBP immunocytochemistry, which correlates highly with expression of Ca<jats:sup>2+<\/jats:sup>\u2010permeable AMPA\/kainate receptors, shows a laminar pattern of distribution similar to that found with kainate\u2010stimulated cobalt uptake. Nearly all neurons of the vagal gustatory ganglion show Co<jats:sup>2+<\/jats:sup> uptake and are immunopositive for CaBPs. Transection of the vagus nerve proximal to the ganglion results in loss of such punctate Co<jats:sup>2+<\/jats:sup> uptake and of punctate CaBP staining as soon as 4 days postlesion. These results are consonant with the presence of Ca<jats:sup>2+<\/jats:sup>\u2010fluxing glutamate receptors on the presynaptic terminals of primary gustatory terminals, providing an avenue for modulation of primary gustatory input. J. Comp. 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