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After capsaicin injection into the tongue, lower gum, upper and lower lips, or mental region, pERK\u2010like immunoreactive (pERK\u2010LI) cells were distributed mainly in the dorsal half of the trigeminal spinal nucleus interporalis (Vi) and caudalis (Vc) transition zone (Vi\/Vc zone), middle Vc, and Vc and upper cervical cord transition zone (Vc\/C2 zone). pERK\u2010LI cells were distributed throughout the dorsal to ventral portion of the Vi\/Vc zone, middle Vc, and Vc\/C2 zone following capsaicin injection into the anterior hard palate, upper gum, buccal mucosa, or vibrissal pad and in the ventral portion of the Vi\/Vc zone, middle Vc, and Vc\/C2 zone following snout, ophthalmic, or ocular injection of capsaicin. The rostrocaudal distribution area of pERK\u2010LI cells was more extensive from the Vi\/Vc zone to the Vc\/C2 zone after intraoral injection than that after facial injection, and the rostrocaudal distribution of pERK\u2010LI cells from the Vi\/Vc zone to the Vc\/C2 zone had a somatotopic arrangement, with the snout being represented most rostrally and ophthalmic, ocular, or mental regions represented most caudally. These findings suggest that the pERK\u2010LI cells expressed from the Vi\/Vc zone to the Vc\/C2 zone following injection of capsaicin in facial and intraoral structures may be differentially involved in pain perception in facial and intraoral sites. J. Comp. Neurol. 507:1428\u20131440, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21620","type":"journal-article","created":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T17:20:35Z","timestamp":1200331235000},"page":"1428-1440","source":"Crossref","is-referenced-by-count":89,"title":["Organization of pERK\u2010immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats"],"prefix":"10.1002","volume":"507","author":[{"given":"Noboru","family":"Noma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiko","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry J.","family":"Sessle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1986.55.2.227"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.05.013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903120210"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1113\/jphysiol.1988.sp017168","article-title":"An electrophysiological and anatomical study of intestinal afferent fibres in the rat","volume":"401","author":"Cervero F","year":"1988","journal-title":"J Physiol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-17-07737.2002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.12.034"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)62788-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.06.030183.002121"},{"key":"e_1_2_5_10_1","first-page":"63","article-title":"Neural and behavioral correlates of pain in the trigeminal system","volume":"58","author":"Dubner R","year":"1980","journal-title":"Res Publ Assoc Res Nerv Ment Dis"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1989.62.2.450"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199810)37:1<158::AID-NEU12>3.0.CO;2-A"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-19-07252.1997"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10227"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902370205"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902400106"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1984.51.5.890"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(90)90010-B"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.03.004"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/328632a0"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01913-7"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00201-7"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.4.1717"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.3.1244"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91165-X"},{"key":"e_1_2_5_26_1","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1152\/jn.1986.55.6.1153","article-title":"Structure\u2010function relationships in rat medullary and cervical dorsal horns. 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