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The present studies examine the expression and regulation of another receptor known to bind NGF, p75<jats:sup>NTR<\/jats:sup>, after various durations of bladder inflammation induced by cyclophosphamide (CYP). CYP\u2010induced cystitis increased (<jats:italic>P<\/jats:italic> \u2264 0.001) p75<jats:sup>NTR<\/jats:sup> expression in the superficial lateral and medial dorsal horn in L1\u2013L2 and L6\u2013S1 spinal segments. The number of p75<jats:sup>NTR<\/jats:sup>\u2010immunoreactive (\u2010IR) cells in the lumbosacral dorsal root ganglia (DRG) also increased (<jats:italic>P<\/jats:italic> \u2264 0.05) with CYP\u2010induced cystitis (acute, intermediate, and chronic). Quantitative, real\u2010time polymerase chain reaction also demonstrated significant increases (<jats:italic>P<\/jats:italic> \u2264 0.01) in p75<jats:sup>NTR<\/jats:sup> mRNA in DRG with intermediate and chronic CYP\u2010induced cystitis. Retrograde dye\u2010tracing techniques with Fastblue were used to identify presumptive bladder afferent cells in the lumbosacral DRG. In bladder afferent cells in DRG, p75<jats:sup>NTR<\/jats:sup>\u2010IR was also increased (<jats:italic>P<\/jats:italic> \u2264 0.01) with cystitis. In addition to increases in p75<jats:sup>NTR<\/jats:sup>\u2010IR in DRG cell bodies, increases (<jats:italic>P<\/jats:italic> \u2264 0.001) in pericellular (encircling DRG cells) p75<jats:sup>NTR<\/jats:sup>\u2010IR in DRG also increased. Confocal analyses demonstrated that pericellular p75<jats:sup>NTR<\/jats:sup>\u2010IR was not colocalized with the glial marker, glial fibrillary acidic protein (GFAP). These studies demonstrate that p75<jats:sup>NTR<\/jats:sup> expression in micturition reflexes is present constitutively and modified by bladder inflammation. The functional significance of p75<jats:sup>NTR<\/jats:sup> expression in micturition reflexes remains to be determined. J. Comp. Neurol. 507:1379\u20131392, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21627","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T22:48:54Z","timestamp":1200091734000},"page":"1379-1392","source":"Crossref","is-referenced-by-count":33,"title":["p75<sup>NTR<\/sup> expression in rat urinary bladder sensory neurons and spinal cord with cyclophosphamide\u2010induced cystitis"],"prefix":"10.1002","volume":"507","author":[{"given":"Mary Beth","family":"Klinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Girard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret 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