{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:20:35Z","timestamp":1769070035303,"version":"3.49.0"},"reference-count":83,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,5,13]],"date-time":"2008-05-13T00:00:00Z","timestamp":1210636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2008,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fiber connections of the cerebellar cortex are organized into distinct parasagittal domains. Each domain expresses a unique subset of various genes. Brain structures that are directly connected to the cerebellar cortex, such as the deep cerebellar nuclei and the inferior olivary nucleus, show a similarly differential pattern of connectivity and gene expression. For example, several members of the cadherin family of adhesion molecules are expressed differentially in the subdivisions of the cerebellar system in chicken and mouse. Little is known, however, about how the molecular maps in the different parts of the cerebellum relate to each other in terms of connectivity. Here, we mapped the expression of three cadherins (cadherin\u20108, protocadherin\u20107, and protocadherin\u201010) in the cerebellar system of the chicken embryo. By simultaneously tracing axonal connections with biotinylated dextran amine, we demonstrate that cortical domains and deep nuclear portions as well as their fiber connections have a matching expression profile for protocadherin\u201010 in the posterior part of the cerebellum. Based on the tracing results for protocadherin\u201010 and the comparative expression mapping of all three cadherins, the cortical projection domains of the three deep cerebellar nuclei were determined in the posterior part of the cerebellum. Results were extrapolated to the rest of the cerebellar cortex. Our results provide direct experimental support for the notion that cadherins are markers for neural circuits in the brain. Moreover, we show that the expression pattern of all three cadherins confers unique identities to the Purkinje cell domains. J. Comp. Neurol. 509:283\u2013301, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21743","type":"journal-article","created":{"date-parts":[[2008,5,13]],"date-time":"2008-05-13T19:16:24Z","timestamp":1210706184000},"page":"283-301","source":"Crossref","is-referenced-by-count":18,"title":["Neural circuits revealed by axon tracing and mapping cadherin expression in the embryonic chicken cerebellum"],"prefix":"10.1002","volume":"509","author":[{"given":"Franziska","family":"Neudert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Redies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.8.2081"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"9873","DOI":"10.1523\/JNEUROSCI.23-30-09873.2003","article-title":"R\u2010cadherin is a Pax6\u2010regulated, growth\u2010promoting cue for pioneer axons","volume":"23","author":"Andrews GL","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00944-2"},{"key":"e_1_2_6_5_1","first-page":"52","article-title":"Topographic aspects of the olivocerebellar system in the pigeon","volume":"17","author":"Arends JJA","year":"1989","journal-title":"Exp Brain Res Suppl"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903060203"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903060204"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1139\/o00-071"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960923)373:3<373::AID-CNE5>3.0.CO;2-#"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981123)401:3<367::AID-CNE5>3.0.CO;2-S"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1998.0665"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00375-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902910405"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(93)90048-W"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1523\/JNEUROSCI.16-10-03296.1996","article-title":"BEN as a presumptive target recognition molecule during the development of the olivocerebellar system","volume":"16","author":"Chedotal A","year":"1996","journal-title":"J Neurosci"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.09.056"},{"key":"e_1_2_6_17_1","unstructured":"FeirabendHKP.1983.Anatomy and development of longitudinal patterns in the architecture of the cerebellum of the white leghorn (Gallus domesticus)PhD thesis. Leiden: University of Leiden.280p."},{"key":"e_1_2_6_18_1","first-page":"169","article-title":"Development of longitudinal patterns in the cerebellum of the chicken (Gallus domesticus): a cytoarchitectural study on the genesis of cerebellar modules","volume":"28","author":"Feirabend HK","year":"1990","journal-title":"Eur J Morphol"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00365-4"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000121519","article-title":"The organization of the olivocerebellar projection in the chicken","volume":"22","author":"Furber SE","year":"1983","journal-title":"Brain Behav Evol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199707)209:3<269::AID-AJA3>3.0.CO;2-G"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.009"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(86)90011-7"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.05.023"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-03-00995.1999"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2741\/972"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1013-06.2006"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-17-06488.2000"},{"key":"e_1_2_6_30_1","volume-title":"A stereotaxic atlas of the brain of the pigeon (Columba livia)","author":"Karten HJ","year":"1967"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.03.052"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971020)387:2<291::AID-CNE10>3.0.CO;2-Y"},{"key":"e_1_2_6_33_1","volume-title":"A stereotaxic atlas of the brain of the chick (Gallus domesticus)","author":"Kuenzel WJ","year":"1988"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/14734220600804668"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900890204"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-22-09342.1998"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410000292"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21248"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2000.0849"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21352"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.12.3935"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5429.906"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.15.2963"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-24-10877.1999"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.11.017"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3777"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01325-3"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200406030"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21266"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20707"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.1006"},{"key":"e_1_2_6_52_1","first-page":"272","volume-title":"The chick brain in stereotaxic coordinates: An atlas featuring neuromeric subdivisions and mammalian homologies","author":"Puelles L","year":"2007"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00070-2"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10014"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0315"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-09-03525.1992"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903330307"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970505)381:2<230::AID-CNE9>3.0.CO;2-4"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80216-0"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.034"},{"key":"e_1_2_6_61_1","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1242\/dev.120.8.2225","article-title":"Wnt\u20101\u2010dependent regulation of local E\u2010cadherin and alpha N\u2010catenin expression in the embryonic mouse brain","volume":"120","author":"Shimamura K","year":"1994","journal-title":"Development"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(04)48022-4"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.19.3765"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21219"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10952"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1997.0626"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0243-07.2007"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2043"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00748-1"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90207-3"},{"key":"e_1_2_6_71_1","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1523\/JNEUROSCI.22-17-07617.2002","article-title":"Targeting axons to specific fiber tracts in vivo by altering cadherin expression","volume":"22","author":"Treubert\u2010Zimmermann U","year":"2002","journal-title":"J Neurosci"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1960"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5021-7"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901010209"},{"key":"e_1_2_6_75_1","unstructured":"VoogdJ.1964.The cerebellum of the cat. Structure and fiber connections. PhD thesis. Leiden: University of Leiden.215p."},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01318-6"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)63356-7"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000029645.72074.2b"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-11-04645.2003"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00526-0"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902010303"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.27.19473"},{"key":"e_1_2_6_83_1","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1523\/JNEUROSCI.15-06-04556.1995","article-title":"Lamina\u2010specific expression of adhesion molecules in developing chick optic tectum","volume":"15","author":"Yamagata M","year":"1995","journal-title":"J Neurosci"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.08.020"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.21743","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.21743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T15:26:57Z","timestamp":1699975617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.21743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,14]]},"references-count":83,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,7,20]]}},"alternative-id":["10.1002\/cne.21743"],"URL":"https:\/\/doi.org\/10.1002\/cne.21743","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,14]]}}}