{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T07:06:41Z","timestamp":1698908801929},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T00:00:00Z","timestamp":1216166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2008,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A fundamental organizational principle of the central nervous system is that gray matter is the province of neuronal somata, white matter their processes. However, the rat and primate dorsal columns (archetypal spinal \u201cwhite matter\u201d tracts) are actually of intermediate character, insofar as they contain a surprisingly prominent neuropil of unknown function. Here I report on the morphology, inputs, projections, and functional properties of these neurons. Small fusiform and larger lentiform neurons are most abundant in the gracile fasciculus of the cervical and lumbar enlargements and are absent from the cuneate fasciculus and corticospinal tract. Many have dendrites that run along the dorsal pia, and, although in transverse sections these neurons appear isolated from the gray matter, they are also connected to area X by varicose and sometimes loosely fasciculated dendrites. These neurons receive neurochemically diverse, compartmentalized synaptic inputs (primary afferent, intrinsic and descending), half express the substance P receptor, and some project supraspinally. Unlike substantia gelatinosa neurons, they do not express protein kinase C gamma. Functionally, they have small receptive fields, which are somatotopically appropriate with respect to their anterior\u2010posterior position along the neuraxis. They respond to innocuous and\/or noxious mechanical stimulation of the distal extremities, and some are prone to central sensitization or \u201cwindup.\u201d Morphologically, neurochemically, and functionally, therefore, these cells most closely resemble neurons in laminae III\u2013VI in the dorsal horn. The proximity of their dorsal dendrites to the pia mater may also reflect an ability to integrate internal (e.g., changes in cerebrospinal fluid compostition) and external (e.g., somatic) stimuli. J. Comp. Neurol. 510:283\u2013296, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21785","type":"journal-article","created":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T14:22:18Z","timestamp":1216218138000},"page":"283-296","source":"Crossref","is-referenced-by-count":16,"title":["Anatomical and functional characterization of neuropil in the gracile fasciculus"],"prefix":"10.1002","volume":"510","author":[{"given":"Matt S.","family":"Ramer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.1.260"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/ar.1090940210","article-title":"Estimation of nuclear population from microtome sections","volume":"94","author":"Abercrombie M","year":"1946","journal-title":"Anat Rec"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69537-7_1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"7655","DOI":"10.1523\/JNEUROSCI.14-12-07655.1994","article-title":"The correlation between the distribution of the NK1 receptor and the actions of tachykinin agonists in the dorsal horn of the rat indicates that substance P does not have a functional role on substantia gelatinosa (lamina II) neurons","volume":"14","author":"Bleazard L","year":"1994","journal-title":"J Neurosci"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903560302"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.11.069"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017297"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-23-09733.1998"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000101704"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1176\/ajp.2006.163.4.637","article-title":"Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression","volume":"163","author":"Geracioti TD","year":"2006","journal-title":"Am J Psychiatry"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90029-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/328632a0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3100537"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(20000313)418:3<281::AID-CNE4>3.0.CO;2-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1999.19410015.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00039-L"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7539937"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20743"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(66)90068-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/206097a0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.116.1.201"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.1523\/JNEUROSCI.17-14-05536.1997","article-title":"Cells in laminae III and IV of the rat spinal cord that possess the neurokinin\u20101 receptor and have dorsally directed dendrites receive a major synaptic input from tachykinin\u2010containing primary afferents","volume":"17","author":"Naim M","year":"1997","journal-title":"J Neurosci"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00013-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20987"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1523\/JNEUROSCI.19-07-02637.1999","article-title":"GABAergic neurons that contain neuropeptide Y selectively target cells with the neurokinin 1 receptor in laminae III and IV of the rat spinal cord","volume":"19","author":"Polgar E","year":"1999","journal-title":"J Neurosci"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0491-07.2007"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1523\/JNEUROSCI.11-04-01068.1991","article-title":"Substance P\u2010 and enkephalin\u2010like immunoreactivities are colocalized in certain neurons of the substantia gelatinosa of the rat spinal cord: an ultrastructural double\u2010labeling study","volume":"11","author":"Ribeiro\u2010da\u2010Silva A","year":"1991","journal-title":"J Neurosci"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020170091"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81003-X"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02981.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-13-04904.2000"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1113\/eph8702351"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.11.001"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4584-05.2006"},{"key":"e_1_2_6_37_1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1523\/JNEUROSCI.14-02-00834.1994","article-title":"Characterization of antibodies to the rat substance P (NK\u20101) receptor and to a chimeric substance P receptor expressed in mammalian cells","volume":"14","author":"Vigna SR","year":"1994","journal-title":"J Neurosci"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1969.32.6.803"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1967.sp008146"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10294"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0037-7"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21382"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.21785","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.21785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T14:49:50Z","timestamp":1697208590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.21785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,16]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9,20]]}},"alternative-id":["10.1002\/cne.21785"],"URL":"https:\/\/doi.org\/10.1002\/cne.21785","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,16]]}}}