{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T01:10:48Z","timestamp":1782090648811,"version":"3.54.5"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T00:00:00Z","timestamp":1221782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2008,11,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A comprehensive model has yet to emerge, but it seems likely that numerous mechanisms contribute to the specificity of olfactory sensory neuron (OSN) axon innervation of the olfactory bulb. Elsewhere in the nervous system the Wnt\/Fz family has been implicated in patterning of anterior\u2010posterior axes, cell type specification, cell proliferation, and axon guidance. Because of our work describing cadherin\u2010catenin family member expression in the primary olfactory pathway, and because mechanisms of Wnt\u2010Fz interactions can depend in part on catenins, we were encouraged to explore Wnt\u2010Fz expression and function in OSN axon extension. Here, we show that OSNs express Fz\u20101, Fz\u20103, and Wnt\u20105a, whereas olfactory ensheathing cells (OECs) express Wnt\u20104. Fz\u20107 is also expressed in the olfactory nerve by cells that delineate large axon fascicles, but are negative for OEC markers. Fz\u20101 showed a developmental downregulation. However, in adults it is expressed at different levels across the olfactory epithelium and in restricted glomeruli across the olfactory bulb, suggesting an important role in the formation and maintenance of OSN connections to the olfactory bulb. Reporter TOPGAL mice demonstrated that some OECs located in the inner olfactory nerve layer can respond to Wnt ligands. Of further interest, we show here with in vitro assays that Wnt\u20105a increases OSN axon outgrowth and alters growth cone morphology. Our data point to a key role for Wnt\/Fz molecules in the development of the mouse olfactory system, providing complementary mechanisms required for OSN axon extension and coalescence. J. Comp. Neurol. 511:301\u2013317, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.21834","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T15:57:23Z","timestamp":1221839843000},"page":"301-317","source":"Crossref","is-referenced-by-count":32,"title":["Wnt\/frizzled family members mediate olfactory sensory neuron axon extension"],"prefix":"10.1002","volume":"511","author":[{"given":"Diego J.","family":"Rodriguez\u2010Gil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles 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