{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:31:47Z","timestamp":1773811907190,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T00:00:00Z","timestamp":1247702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2009,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the extent of misdirection of regenerating axons when that regeneration was enhanced by using treadmill training. Retrograde fluorescent tracers were applied to the cut proximal stumps of the tibial and common fibular nerves 2 or 4 weeks after transection and surgical repair of the mouse sciatic nerve. The spatial locations of retrogradely labeled motoneurons were studied in untreated control mice and in mice receiving 2 weeks of treadmill training, according to either a continuous protocol (10 m\/minute, 1 hour\/day, 5 days\/week) or an interval protocol (20 m\/minute for 2 minutes, followed by a 5\u2010minute rest, repeated four times, 5 days\/week). More retrogradely labeled motoneurons were found in both treadmill\u2010trained groups. The magnitude of this increase was as great as or greater than that found after using other enhancement strategies. In both treadmill\u2010trained groups, the proportions of motoneurons labeled from tracer applied to the common fibular nerve that were found in spinal cord locations reserved for tibial motoneurons in intact mice were no greater than in untreated control mice and significantly less than those found after electrical stimulation or chondroitinase treatment. Treadmill training in the first 2 weeks following peripheral nerve injury produces a marked enhancement of motor axon regeneration without increasing the propensity of those axons to choose pathways leading to functionally inappropriate targets. J. Comp. Neurol. 517:245\u2013255, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.22149","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T16:40:37Z","timestamp":1247848837000},"page":"245-255","source":"Crossref","is-referenced-by-count":65,"title":["Treadmill training enhances axon regeneration in injured mouse peripheral nerves without increased loss of topographic specificity"],"prefix":"10.1002","volume":"517","author":[{"given":"Arthur W.","family":"English","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia","family":"Cucoranu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Mulligan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manning","family":"Sabatier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,9,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090940210"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02602.2000"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-06-02730.1993"},{"key":"e_1_2_6_5_1","first-page":"1381","volume-title":"Green's operative hand surgery","author":"Brushart TM","year":"1998"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.02.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7367884"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(83)80152-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.12.023"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20678"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20339"},{"key":"e_1_2_6_12_1","unstructured":"EnglishAW MulliganA CucoranuD.2008.Treadmill training enhances axon regeneration in cut peripheral nerves without effecting topographic specificity of reinnervating motoneurons. Abstr Soc Neurosci 76.7."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4880-04.2005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2752(1998)18:7<397::AID-MICR2>3.0.CO;2-F"},{"key":"e_1_2_6_15_1","unstructured":"GeremiaNM GordonT Al\u2010MajedAA BrushartTM VergeVMK.2005.Brief electrical stimulation promotes sensory neuron regeneration and intrinsic growth\u2010associated gene expression. Soc Neurosci Program No. 28.26."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.04.006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2003.03029.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.04.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026523821261"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0886-0440.2003.02073.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1981.0082"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/22.12.1077"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.95.4.0694"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.06.006"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.02.013"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(86)90161-5"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20436"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199801)34:1<41::AID-NEU4>3.0.CO;2-C"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7922"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.22149","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.22149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T20:07:42Z","timestamp":1697227662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.22149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,3]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,11,10]]}},"alternative-id":["10.1002\/cne.22149"],"URL":"https:\/\/doi.org\/10.1002\/cne.22149","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,3]]}}}