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The function of these GDNF family ligands (GFLs) is not fully elucidated but recent evidence suggests GFLs could function in sensory neuron regeneration after nerve injury and peripheral nociceptor sensitization. In this study we used immunohistochemistry to determine if the DRG neurons targeted by each GFL change after sciatic nerve injury. We compared complete sciatic nerve transection and the chronic constriction model and found that the pattern of changes incurred by each injury was broadly similar. In lumbar spinal cord there was a widespread increase in neuronal GFR\u03b11 immunoreactivity (IR) in the L1\u20106 dorsal horn. GFR\u03b13\u2010IR also increased but in a more restricted area. In contrast, GFR\u03b12\u2010IR decreased in patches of superficial dorsal horn and this loss was more extensive after transection injury. No change in calcitonin gene\u2010related peptide\u2010IR was detected after either injury. Analysis of double\u2010immunolabeled L5 DRG sections suggested the main effect of injury on GFR\u03b11\u2010 and GFR\u03b13\u2010IR was to increase expression in both myelinated and unmyelinated neurons. In contrast, no change in basal expression of GFR\u03b12\u2010IR was detected in DRG by analysis of fluorescence intensity and there was a small but significant reduction in GFR\u03b12\u2010IR neurons. Our results suggest that the DRG neuronal populations targeted by GDNF, neurturin, or artemin and the effect of exogenous GFLs could change significantly after a peripheral nerve injury. J. Comp. Neurol. 518:3024\u20133045, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.22378","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T23:52:59Z","timestamp":1269388379000},"page":"3024-3045","source":"Crossref","is-referenced-by-count":30,"title":["Sciatic nerve injury in adult rats causes distinct changes in the central projections of sensory neurons expressing different glial cell line\u2010derived neurotrophic factor family receptors"],"prefix":"10.1002","volume":"518","author":[{"given":"Janet R.","family":"Keast","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley L.","family":"Forrest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peregrine 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