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The coalition of both placode\u2010derived migratory cells and OSN axons within the mesenchyme is collectively termed the \u201cmigratory mass.\u201d Here we address the sequence and coordination of the events that give rise to the migratory mass. Using neuronal and developmental markers, we show subpopulations of neurons emerging from the placode by embryonic day (E)10, a time at which the migratory mass is largely cellular and only a few isolated OSN axons are seen, prior to the first appearance of OSN axon fascicles at E11. These neurons also precede the emergence of the gonadotropin\u2010releasing hormone neurons and ensheathing glia which are also resident in the mesenchyme as part of the migratory mass beginning at about E11. The data reported here begin to establish a spatiotemporal framework for the migration of molecularly heterogeneous placode\u2010derived cells in the mesenchyme. The precocious emigration of the early arriving neurons in the mesenchyme suggests they may serve as \u201cguidepost cells\u201d that contribute to the establishment of a scaffold for the extension and coalescence of the OSN axons. J. Comp. Neurol. 518:4825\u20134841, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.22497","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T20:35:32Z","timestamp":1284496532000},"page":"4825-4841","source":"Crossref","is-referenced-by-count":84,"title":["Composition of the migratory mass during development of the olfactory nerve"],"prefix":"10.1002","volume":"518","author":[{"given":"Alexandra M.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen B.","family":"Treloar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles 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